methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

Base Information

Chemical Name:methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate
CAS No.:148693-70-3
Molecular Formula:C₂₂H₂₄ClNO₃
Molecular Weight:385.89
Hs Code.:

Synonyms:methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

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Chemical Property of methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

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Technology Process of methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

There total 5 articles about methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 103253-35-6
3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid

: 67-56-1
methanol

: 148693-70-3
methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

Guidance literature:: 3-[1-(4-chlorobenzyl)-3-methyl-5-methoxyindol-2-yl]-2,2-dimethylpropanoic acid; With boron tribromide; In dichloromethane; at -60 - 0 ℃;

methanol;
DOI:10.1016/j.bmcl.2005.05.027

Reference yield:

: 15118-53-3
2,2-dimethyl-4-oxohexanoic acid

: 148693-70-3
methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / 2-methyl-propan-2-ol / 15 h / Heating

2: 100 percent / BBr₃ / CH₂Cl₂ / -60 - 0 °C

With boron tribromide; In dichloromethane; tert-butyl alcohol; 1: Fisher indole coupling;
DOI:10.1016/j.bmcl.2005.05.027

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 148693-70-3
methyl 3-[1-(4-chlorobenzyl)-3-methyl-5-hydroxyindol-2-yl]-2,2-dimethylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / Et₃N / toluene / 15 h / Heating

2: 54 percent / 2-methyl-propan-2-ol / 15 h / Heating

3: 100 percent / BBr₃ / CH₂Cl₂ / -60 - 0 °C

With boron tribromide; triethylamine; In dichloromethane; toluene; tert-butyl alcohol; 2: Fisher indole coupling;
DOI:10.1016/j.bmcl.2005.05.027