tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Base Information

Chemical Name:tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate
CAS No.:1374263-80-5
Molecular Formula:C₃₈H₃₅N₇O₃S
Molecular Weight:669.807
Hs Code.:

tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Synonyms:tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

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Chemical Property of tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

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Technology Process of tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

There total 10 articles about tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1374263-79-2
tert-butyl {1-[4-(2-{4-[(aminocarbonothioyl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 105-36-2
ethyl bromoacetate

: 1374263-80-5
tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Guidance literature:: In tetrahydrofuran; ethanol; chloroform; at 70 ℃; for 1.5h;

Reference yield:

: 1374260-84-0
tert-butyl {1-[4-(9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 1374263-80-5
tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / chloroform / 22 h / Reflux

2.1: bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation; Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h

4.1: tetrahydrofuran / 0.75 h

4.2: 0.33 h

5.1: tetrahydrofuran; ethanol; chloroform / 1.5 h / 70 °C

With N-chloro-succinimide; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); hydrogen; sodium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1374263-21-4
tert-butyl (1-{4-[2-(4-nitrophenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate

: 1374263-80-5
tert-butyl {1-[4-(2-{4-[(4-oxo-4,5-dihydro-1,3-thiazol-2-yl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h

2.1: tetrahydrofuran / 0.75 h

2.2: 0.33 h

3.1: tetrahydrofuran; ethanol; chloroform / 1.5 h / 70 °C

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; chloroform;