methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

Base Information

Chemical Name:methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate
CAS No.:1372716-05-6
Molecular Formula:C₂₀H₂₂NO₆P
Molecular Weight:403.372
Hs Code.:

Synonyms:methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

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Chemical Property of methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

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Technology Process of methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

There total 2 articles about methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 2524-64-3
chlorophosphoric acid diphenyl ester

: 22366-95-6
methyl 2-oxoazepane-1-carboxylate

: 1372716-05-6
methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

Guidance literature:: methyl 2-oxoazepane-1-carboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1002/ejoc.201101293

Reference yield:

: 105-60-2,9012-16-2
caprolactam

: 1372716-05-6
methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

1.2: 1.5 h / -78

2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

2.2: 2 h / -78 °C

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1002/ejoc.201101293

Reference yield: 95.0%

: 1372716-05-6
methyl 7-(diphenoxyphosphoryloxy)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate

: 41593-58-2
diphenylphosphineborane

: 1372716-07-8
methyl 7-(diphenylphosphino)-2,3,4,5-tetrahydro-1H-azepine-1-carboxylate-borane complex

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In acetonitrile; at 65 - 70 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.201101293