5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

Base Information

Chemical Name:5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide
CAS No.:220377-94-6
Molecular Formula:C₃₄H₃₄ClN₃O₂S
Molecular Weight:584.182
Hs Code.:

Synonyms:5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

Suppliers and Price of 5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

Chemical Property:

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Technology Process of 5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

There total 9 articles about 5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 220377-92-4
(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

: 220377-94-6
5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

: 42060-30-0
N-(4-chloro-benzyl)-methanesulfonamide

: 220377-94-6
5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

2.1: LDA / tetrahydrofuran / 1 h / -78 °C

2.2: 48 percent / tetrahydrofuran / 2 h / -78 - 20 °C

3.1: 91 percent / Cs₂CO₃ / methanol / 18 h / 20 °C

4.1: 84 percent / H₂ / 10 percent Pd/C / tetrahydrofuran / 18 h / 20 °C

With dmap; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00295-4

Reference yield:

: 104-86-9
4-chlorobenzylamine

: 220377-94-6
5-(1-trityl-1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 81 percent / Et₃N / CH₂Cl₂ / 2 h

2.1: 89 percent / N,N-4-dimethylaminopyridine / CH₂Cl₂ / 0.5 h

3.1: LDA / tetrahydrofuran / 1 h / -78 °C

3.2: 48 percent / tetrahydrofuran / 2 h / -78 - 20 °C

4.1: 91 percent / Cs₂CO₃ / methanol / 18 h / 20 °C

5.1: 84 percent / H₂ / 10 percent Pd/C / tetrahydrofuran / 18 h / 20 °C

With dmap; hydrogen; caesium carbonate; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(01)00295-4