(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Base Information

Chemical Name:(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide
CAS No.:220377-92-4
Molecular Formula:C₃₄H₃₂ClN₃O₂S
Molecular Weight:582.166
Hs Code.:

Synonyms:(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Suppliers and Price of (E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

There total 9 articles about (E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 220377-90-2
carbonic acid tert-butyl ester 1-[(4-chlorobenzylsulfamoyl)methyl]-4-(1-trityl-1H-imidazol-4-yl)butyl ester

: 220377-92-4
(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Guidance literature:: With caesium carbonate; In methanol; at 20 ℃; for 18h;
DOI:10.1016/S0968-0896(01)00295-4

Reference yield: 91.0%

: 220377-92-4
(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Guidance literature:

Reference yield:

: 33016-47-6
(1-tritylimidazol-4-yl)carboxaldehyde

: 220377-92-4
(E)-5-(1-trityl-1H-imidazol-4-yl)pent-1-ene-1-sulfonic acid 4-chlorobenzylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / tetrahydrofuran / 1 h / -20 °C

1.2: 42 percent / tetrahydrofuran / 18 h / 20 °C

2.1: 100 percent / H₂ / 10 percent Pd/C / ethanol / 18 h / 20 °C / atmospheric pressure

3.1: 91 percent / 2M HCl / acetone / 20 h / 20 °C

4.1: LDA / tetrahydrofuran / 1 h / -78 °C

4.2: 48 percent / tetrahydrofuran / 2 h / -78 - 20 °C

5.1: 91 percent / Cs₂CO₃ / methanol / 18 h / 20 °C

With hydrogenchloride; n-butyllithium; hydrogen; caesium carbonate; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; acetone;
DOI:10.1016/S0968-0896(01)00295-4