(R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one

Base Information

Chemical Name:(R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one
CAS No.:857478-14-9
Molecular Formula:C₂₃H₃₀O₂Si
Molecular Weight:366.576
Hs Code.:
DSSTox Substance ID:DTXSID901182795
Nikkaji Number:J2.190.885A

Synonyms:DTXSID901182795;(R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one;(2R)-2-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-6-hepten-3-one;857478-14-9

Suppliers and Price of (R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:9
Exact Mass:366.201506730
Heavy Atom Count:26
Complexity:435

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C(=O)CCC=C)O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C
Isomeric SMILES:C[C@H](C(=O)CCC=C)O[Si](C1=CC=CC=C1)(C2=CC=CC=C2)C(C)(C)C

Technology Process of (R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one

There total 4 articles about (R)-2-(tert-Butyldiphenylsiloxy)-6-heptene-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 857478-12-7
(2R)-N-methoxy-N-methyl-2-(t-butyldiphenylsilyloxy)propanamide

: 5162-44-7
1-bromo-4-butene

: 857478-14-9
(R)-2-(tert-butyldiphenylsiloxy)-6-hepten-3-one

Guidance literature:: 1-bromo-4-butene; With magnesium;

(2R)-N-methoxy-N-methyl-2-(t-butyldiphenylsilyloxy)propanamide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ol050991r

Reference yield:

: 561038-05-9
(R)-2-(tert-butyldiphenylsilanyloxy)propionic acid methyl ester

: 857478-14-9
(R)-2-(tert-butyldiphenylsiloxy)-6-hepten-3-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: LiOH / tetrahydrofuran; H₂O

2.1: 2.91 g / EDC; DIPEA / CH₂Cl₂

3.1: Mg

3.2: 89 percent / tetrahydrofuran / 3 h / 20 °C

With lithium hydroxide; magnesium; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; 3.2: Grignard reaction;
DOI:10.1021/ol050991r

Reference yield:

: 110407-68-6
(R)-2-((tert-butyldiphenylsilyl)oxy)propanoic acid

: 857478-14-9
(R)-2-(tert-butyldiphenylsiloxy)-6-hepten-3-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2.91 g / EDC; DIPEA / CH₂Cl₂

2.1: Mg

2.2: 89 percent / tetrahydrofuran / 3 h / 20 °C

With magnesium; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; 2.2: Grignard reaction;
DOI:10.1021/ol050991r