(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

Base Information

Chemical Name:(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester
CAS No.:1054651-16-9
Molecular Formula:C₃₁H₄₆N₄O₁₁
Molecular Weight:650.726
Hs Code.:

(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

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Chemical Property of (R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

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Technology Process of (R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

There total 9 articles about (R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118700-84-8
(S)-3-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)propanoic acid

: 1054651-16-9
(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

7: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j

Reference yield:

: 110473-10-4
N-Boc-D-Glu α-methyl ester

: 1054651-16-9
(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / HCl / ethyl acetate / 1 h / 0 °C

2: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

3: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

4: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

5: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

6: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

7: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid; ethyl acetate;
DOI:10.1039/a702410j

Reference yield:

: 1026326-12-4
C₂₂H₃₂N₂O₇

: 1054651-16-9
(R)-2-[3-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-propionylamino]-4-[(2-isobutoxycarbonyloxy-2-oxo-ethyl)-methyl-carbamoyl]-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

2: 91 percent / H₂ / 5percent Pd/C / methanol; acetic acid / 21 h

3: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

4: N-methylmorpholine / tetrahydrofuran / 2 h / Ambient temperature

5: 95 percent / H₂ / 5percent Pd/C / methanol / 12 h

6: N-methylmorpholine / tetrahydrofuran / 0.17 h / -15 °C

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;
DOI:10.1039/a702410j