Technology Process of 4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}benzenesulfonamide
There total 8 articles about 4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}benzenesulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
[(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenyl)sulfonyl]methyl acetate;
With
sodium acetate; potassium carbonate;
In
methanol;
at 20 ℃;
for 1.5h;
With
(hydroxylamino)sulfonic acid;
In
methanol;
at 20 ℃;
for 2h;
DOI:10.1021/jm030276s
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C
2.1: 85 percent / methanol / 70 °C
3.1: trimethylaluminum / hexane; CH2Cl2 / 0 - 20 °C
3.2: 93 percent / hexane; CH2Cl2 / 20 °C
4.1: 48 percent / tetrahydrofuran / 0 - 20 °C
5.1: 45 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH2Cl2 / 1 h / 20 °C
6.1: 56 percent / sodium acetate / 8 h / Heating
7.1: 78 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH2Cl2 / 16 h / 20 °C
8.1: sodium acetate; potassium carbonate / methanol / 1.5 h / 20 °C
8.2: 64 percent / hydroxyaminosulfonic acid / methanol / 2 h / 20 °C
With
trimethylaluminum; sodium methylate; sodium acetate; potassium carbonate; magnesium monoperoxyphthalate hexahydrate;
In
tetrahydrofuran; methanol; hexane; dichloromethane; toluene;
6.1: Pummerer rearrangement;
DOI:10.1021/jm030276s
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 85 percent / methanol / 70 °C
2.1: trimethylaluminum / hexane; CH2Cl2 / 0 - 20 °C
2.2: 93 percent / hexane; CH2Cl2 / 20 °C
3.1: 48 percent / tetrahydrofuran / 0 - 20 °C
4.1: 45 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH2Cl2 / 1 h / 20 °C
5.1: 56 percent / sodium acetate / 8 h / Heating
6.1: 78 percent / magnesium monoperoxyphthalate hexahydrate / methanol; CH2Cl2 / 16 h / 20 °C
7.1: sodium acetate; potassium carbonate / methanol / 1.5 h / 20 °C
7.2: 64 percent / hydroxyaminosulfonic acid / methanol / 2 h / 20 °C
With
trimethylaluminum; sodium acetate; potassium carbonate; magnesium monoperoxyphthalate hexahydrate;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
5.1: Pummerer rearrangement;
DOI:10.1021/jm030276s
![[(4-{1-cyclohexyl-3-[4-(1,1,2,2-tetramethyl-1-silapropoxy)butanoyl]pyrazol-5-yl}phenyl)sulfonyl]methyl acetate](/Databaselist/images/loading.webp)
