METHYL 1-CYCLOHEXYL-5-(4-METHYLSULFANYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

Base Information

• Chemical Name: METHYL 1-CYCLOHEXYL-5-(4-METHYLSULFANYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE
• CAS No.: 346684-16-0
• Molecular Formula: C18H22N2O2S
• Molecular Weight: 330.451
• Hs Code.: 2933199090
• Mol file: 346684-16-0.mol

Synonyms:METHYL 1-CYCLOHEXYL-5-(4-METHYLSULFANYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

Chemical Property of METHYL 1-CYCLOHEXYL-5-(4-METHYLSULFANYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 501.885°C at 760 mmHg
• Flash Point: 257.331°C
• PSA: 69.42000
• Density: 1.229g/cm³
• LogP: 4.56380

Purity/Quality:

98% ^*data from raw suppliers

Methyl1-cyclohexyl-5-(4-methylsulfanyl-phenyl)-1H-pyrazole-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-CYCLOHEXYL-5-(4-METHYLSULFANYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE

There total 3 articles about METHYL 1-CYCLOHEXYL-5-(4-METHYLSULFANYL-PHENYL)-1H-PYRAZOLE-3-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

cyclohexylhydrazine hydrochloride (24214-73-1,30929-57-8) + methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate (346684-15-9) → methyl 1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-carboxylate (346684-16-0)

Guidance literature:

In methanol; at 70 ℃;

DOI:10.1021/jm030276s

Reference yield: 85.0%

→ methyl 1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-carboxylate (346684-16-0)

Guidance literature:

Reference yield:

4-(Methylthio)acetophenone (1778-09-2) → methyl 1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-carboxylate (346684-16-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / sodium methoxide / toluene / 2 h / 20 °C

2: 85 percent / methanol / 70 °C

With sodium methylate; In methanol; toluene;

DOI:10.1021/jm030276s

upstream raw materials:

cyclohexylhydrazine hydrochloride

methyl (2Z)-2-hydroxy-4-(4-methylthiophenyl)-4-oxobut-2-enoate

4-(Methylthio)acetophenone

Downstream raw materials:

(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)-N-methoxy-N-methylcarboxamide

(1-cyclohexyl-5-(4-methylthiophenyl)pyrazol-3-yl)methanol

1-cyclohexyl-5-(4-methylthiophenyl)pyrazole-3-carbaldehyde

4-(1-cyclohexyl-3-vinylpyrazol-5-yl)-1-methylthiobenzene

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