(R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

Base Information

Chemical Name:(R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide
CAS No.:1050392-77-2
Molecular Formula:C₁₅H₁₆N₂O₂S
Molecular Weight:288.37
Hs Code.:

Synonyms:(R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

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Chemical Property of (R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

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Technology Process of (R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

There total 4 articles about (R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 75907-55-0
3-(p-methoxyphenyl)-5-aminothiazole

: benzyl (R,R)-2-methylcyclopropanecarboxylate

: 1050392-77-2
(R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

Guidance literature:: 3-(p-methoxyphenyl)-5-aminothiazole; With trimethylaluminum; In dichloromethane; toluene; at 0 - 5 ℃; for 0.0833333h;

benzyl (R,R)-2-methylcyclopropanecarboxylate; In dichloromethane; toluene; at 40 - 50 ℃; for 5h;

With hydrogenchloride; water; In dichloromethane; toluene;

Reference yield:

: 20913-25-1
2-Methylcyclopropancarbonsaeureethylester

: 1050392-77-2
(R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide; water / dimethyl sulfoxide / 2.25 - 3.25 h / 20 - 30 °C / pH 12

1.2: 20 - 30 °C / pH 2 - 3

2.1: sodium hydroxide / methyltrialkyl(C₈-C₁₀)ammonium chloride (Adogen_.(TM). 464) / water / 4 h / 40 - 45 °C

3.1: n-heptane; isopropyl alcohol / Resolution of racemate

4.1: trimethylaluminum / dichloromethane; toluene / 0.08 h / 0 - 5 °C

4.2: 5 h / 40 - 50 °C

With potassium hydroxide; sodium hydroxide; water; trimethylaluminum; methyltrialkyl(C₈-C₁₀)ammonium chloride (Adogen 464); In n-heptane; dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol; toluene;

Reference yield:

: 29555-02-0
2-methyl-cyclopropanecarboxylic acid

: 1050392-77-2
(R,R)-N-[3-(4-methoxyphenyl)isothiazol-5-yl]-2-methyl-cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methyltrialkyl(C₈-C₁₀)ammonium chloride (Adogen_.(TM). 464) / water / 4 h / 40 - 45 °C

2.1: n-heptane; isopropyl alcohol / Resolution of racemate

3.1: trimethylaluminum / dichloromethane; toluene / 0.08 h / 0 - 5 °C

3.2: 5 h / 40 - 50 °C

With sodium hydroxide; trimethylaluminum; methyltrialkyl(C₈-C₁₀)ammonium chloride (Adogen 464); In n-heptane; dichloromethane; water; isopropyl alcohol; toluene;