tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate
CAS No.:1260168-87-3
Molecular Formula:C₁₆H₂₀ClN₃O₃
Molecular Weight:337.806
Hs Code.:

Synonyms:tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

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Chemical Property of tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

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Technology Process of tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

There total 5 articles about tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1260168-83-9
C₁₂H₁₁ClN₂O₃

: 1260168-85-1
C₁₂H₁₁ClN₂O₃

: 75-65-0
tert-butyl alcohol

: 1260168-87-3
tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

: 1260168-81-7
tert-butyl 3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

Guidance literature:: C₁₂H₁₁ClN₂O₃; C₁₂H₁₁ClN₂O₃; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 20 ℃; for 1h;

tert-butyl alcohol; In 1,4-dioxane; at 90 ℃; for 2.5h;

Reference yield:

: 1260168-75-9
ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate

: 75-65-0
tert-butyl alcohol

: 74-88-4
methyl iodide

: 1260168-87-3
tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

: 1260168-81-7
tert-butyl 3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

Guidance literature:: ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate; methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 6.5h;

With water; sodium hydroxide; In ethanol; at 50 ℃; for 14h;

tert-butyl alcohol; Further stages;

Reference yield:

: 3438-16-2
5-chloro-2-methoxybenzoic acid

: 1260168-87-3
tert-butyl 5-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

: 1260168-81-7
tert-butyl 3-(5-chloro-2-methoxyphenyl)-1-methyl-1H-pyrazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.33 h

1.2: 1.5 h / 50 °C

2.1: 2 h / 90 °C

3.1: hydrazine / ethanol / 2 h / 70 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 6.5 h / 40 °C

4.2: 14 h / 50 °C

With caesium carbonate; 1,1'-carbonyldiimidazole; hydrazine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;