425644-02-6

Upstream product

• 501-53-1 benzyl chloroformate 
• 211512-13-9 N-(4-aminobutan-1-yl)-2-nitrobenzenesulfonamide 
• 349553-74-8 N-(2-nitrobenzenesulfonyl)-1,4-diaminobutane hydrochloride 
• 62146-62-7 (4-aminobutyl)carbamic acid benzyl ester 
• 1694-92-4 2-Nitrobenzenesulfonyl chloride 

Downstream Products

• 437718-38-2 methyl 7-((benzyloxycarbonyl)amino)-3-(2-nitrobenzenesulfonyl)-3-azaheptanoate 
• 425644-04-8 N-benzyloxycarbonyl-N'-3-bromopropyl-N'-(2-nitrobenzenesulfonyl)-1,4-diaminobutane 
• 437718-30-4 7-((benzyloxycarbonyl)amino)-3-(2-nitrobenzenesulfonyl)-3-azaheptanoic acid 
• 878647-82-6 [(4-benzyloxycarbonylamino-butyl)-(2-nitro-benzenesulfonyl)-amino]-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester 
• 437718-31-5 {4-[{[5-(2-tert-butoxycarbonylamino-3-carbamoyl-propionylamino)-pentylcarbamoyl]-methyl}-(2-nitro-benzenesulfonyl)-amino]-butyl}-carbamic acid benzyl ester 
• 425644-03-7 N⁸-benzyloxycarbonyl-N¹-tert-butyloxycarbonyl-N⁴-(2-nitrobenzenesulfonyl)-spermidine 
• 80926-69-8 N⁸-benzyloxycarbonyl-N¹,N⁴-di-tert-butoxycarbonylspermidine 
• 437718-32-6 N-[N^α-(1H-indol-3-ylacetyl)-L-asparaginyl]-N'-[7-((benzyloxycarbonyl)amino)-3-(2-nitrobenzenesulfonyl)-3-azaheptanoyl]-1,5-diaminopentane 
• 103493-33-0 N¹-tert-butyloxycarbonyl-N⁴,N⁸-dibenzyloxycarbonylspermidine 
• 153815-25-9 N⁸-benzyloxycarbonyl-N¹-tert-butoxycarbonylspermidine 

Relevant academic research and scientific papers

Total Synthesis and Biological Evaluation of Paenilamicins from the Honey Bee Pathogen Paenibacillus larvae

Paenilamicins are a group of complex polycationic peptide secondary metabolites with antibacterial and antifungal activities produced by the devastating honey bee brood pathogen Paenibacillus larvae causing the lethal brood disease American Foulbrood (AFB

Syntheses and biological activities of fluorescent-labeled analogs of acylpolyamine toxin NPTX-594 isolated from the venom of Madagascar Joro spider

Acylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs.

An efficient and versatile synthesis of all structural types of acylpolyamine spider toxins

An efficient and versatile synthesis of acylpolyamine spider toxins of all structural types classified by extensive MS analysis has been achieved. By using 2-nitrobenzenesulfonamide as an effective activating and/or protecting group (the Nosyl strategy),

An efficient synthesis of orthogonally protected spermidine

A major problem in the use of spermidine for the synthesis of biologically interesting compounds is the selective orthogonal protection of the three different amino groups. Our approach is based on the Fukuyama reaction, starting from putrescine and 3-amino-l-propanol and affording N8-benzyloxycarbonyl- N1-tert-butyloxycarbonyl- N4-(2-nitrobenzenesulfonyl)spermidine (5) in 5 steps in high yield.

An efficient and versatile synthesis of acylpolyamine spider toxins

An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5