(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Base Information

Chemical Name:(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester
CAS No.:84354-71-2
Molecular Formula:C₄₈H₄₈ClN₆O₁₀P
Molecular Weight:935.37
Hs Code.:

(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Synonyms:(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Suppliers and Price of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

There total 3 articles about (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 68892-41-1
5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine

: 81087-19-6
p-chlorophenyl N-(p-methoxyphenyl)chlorophosphoramidate

: 84354-71-2
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: With 1-methyl-1H-imidazole; In acetonitrile; at 25 ℃; for 4.5h;
DOI:10.1248/cpb.29.3440

Reference yield:

: 104-94-9
4-methoxy-aniline

: 84354-71-2
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / diethyl ether; benzene / 6 h / Ambient temperature

2: 88 percent / 1-methyl imidazole / acetonitrile / 4.5 h / 25 °C

With 1-methyl-1H-imidazole; In diethyl ether; acetonitrile; benzene;
DOI:10.1248/cpb.29.3440

Reference yield:

: 772-79-2
4-chlorophenylphosphorodichloridate

: 84354-71-2
(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 73 percent / diethyl ether; benzene / 6 h / Ambient temperature

2: 88 percent / 1-methyl imidazole / acetonitrile / 4.5 h / 25 °C

With 1-methyl-1H-imidazole; In diethyl ether; acetonitrile; benzene;
DOI:10.1248/cpb.29.3440