N-(4-Methoxyphenyl)amidochloridophosphoric acid 4-chlorophenyl ester

Base Information

• Chemical Name: N-(4-Methoxyphenyl)amidochloridophosphoric acid 4-chlorophenyl ester
• CAS No.: 81087-19-6
• Molecular Formula: C13H12Cl2NO3P
• Molecular Weight: 0
• Mol file: 81087-19-6.mol

Synonyms:N-(4-Methoxyphenyl)amidochloridophosphoric acid 4-chlorophenyl ester

Chemical Property of N-(4-Methoxyphenyl)amidochloridophosphoric acid 4-chlorophenyl ester

Chemical Property:

• PSA: 57.37000
• LogP: 5.25940

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-Methoxyphenyl)amidochloridophosphoric acid 4-chlorophenyl ester

There total 1 articles about N-(4-Methoxyphenyl)amidochloridophosphoric acid 4-chlorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-methoxy-aniline (104-94-9) + 4-chlorophenylphosphorodichloridate (772-79-2) → p-chlorophenyl N-(p-methoxyphenyl)chlorophosphoramidate (81087-19-6)

Guidance literature:

In diethyl ether; benzene; for 6h; Ambient temperature;

DOI:10.1248/cpb.29.3440

Reference yield: 98.0%

p-chlorophenyl N-(p-methoxyphenyl)chlorophosphoramidate (81087-19-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester (81087-39-0)

Guidance literature:

With 1-methyl-1H-imidazole; In 1,4-dioxane; at 25 ℃; for 2h;

DOI:10.1248/cpb.29.3440

Reference yield: 88.0%

5'-O-dimethoxytrityl-N-isobutyryldeoxyguanosine (68892-41-1) + p-chlorophenyl N-(p-methoxyphenyl)chlorophosphoramidate (81087-19-6) → (4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester (84354-71-2)

Guidance literature:

With 1-methyl-1H-imidazole; In acetonitrile; at 25 ℃; for 4.5h;

DOI:10.1248/cpb.29.3440

upstream raw materials:

4-methoxy-aniline

4-chlorophenylphosphorodichloridate

Downstream raw materials:

(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-isobutyrylamino-6-oxo-1,6-dihydro-purin-9-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

N-isobutyryldeoxyguanosine 3'-p-chlorophenyl phosphoro-p-anisidate

(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

(4-Methoxy-phenyl)-phosphoramidic acid (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 4-chloro-phenyl ester

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