methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate

Base Information

• Chemical Name: methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate
• CAS No.: 1206726-26-2
• Molecular Formula: C₂₁H₂₃NO₃
• Molecular Weight: 337.419
• Mol file: 1206726-26-2.mol

Synonyms:methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate

Chemical Property of methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate

There total 7 articles about methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methanol (67-56-1) + ethyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxyacrylate → methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate (1206726-26-2)

Guidance literature:

With magnesium; at 20 ℃; for 19h; Inert atmosphere;

Reference yield: 76.0%

methanol (67-56-1) + (Z)-ethyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxyacrylate → methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate (1206726-26-2)

Guidance literature:

With magnesium; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c0ob00146e

Reference yield:

1H-indole-5-carbonitrile (15861-24-2,142396-06-3) → methyl 3-(2-benzyl-1H-indol-5-yl)-2-ethoxypropanoate (1206726-26-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 25 h / 20 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; pentane / 0.92 h / -78 °C / Inert atmosphere

2.2: 15.8 h / -78 - 20 °C / Inert atmosphere

3.1: sodium hydroxide / methanol / 18 h / 110 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C / Inert atmosphere; Molecular sieve

5.2: 45 h / 0 - 20 °C / Inert atmosphere

6.1: magnesium / 3 h / 20 °C / Inert atmosphere

With tetrabutylammomium bromide; sodium hydride; diisobutylaluminium hydride; magnesium; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; mineral oil; pentane;

DOI:10.1039/c0ob00146e

upstream raw materials:

methanol

1H-indole-5-carbonitrile

2-benzyl-1H-indole-5-carbaldehyde

2-benzyl-1H-indole-5-carbonitrile