(S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

Base Information

Chemical Name:(S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone
CAS No.:911847-22-8
Molecular Formula:C₂₂H₂₇NO₅
Molecular Weight:385.46
Hs Code.:

Synonyms:(S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

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Chemical Property of (S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

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Technology Process of (S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

There total 5 articles about (S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 911847-39-7
(S)-(5-iodo-2-methoxyphenyl)(2-(methoxymethyl)pyrrolidin-1-yl)methanone

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 911847-22-8
(S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

Guidance literature:: With palladium diacetate; potassium carbonate; triphenylphosphine; potassium carbonate; In propan-1-ol; Heating;
DOI:10.1021/ol0615228

Reference yield:

: ((S)-2-Hydroxymethyl-pyrrolidin-1-yl)-(5-iodo-2-methoxy-phenyl)-methanone

: 911847-22-8
(S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: NaH / tetrahydrofuran / 0 - 20 °C

2: 96 percent / K₂CO₃; Pd(OAc)2; Ph₃P / K₂CO₃ / propan-1-ol / Heating

With palladium diacetate; sodium hydride; potassium carbonate; triphenylphosphine; potassium carbonate; In tetrahydrofuran; propan-1-ol; 2: Suzuki reaction;
DOI:10.1021/ol0615228

Reference yield:

: 2786-00-7
2-methoxy-5-iodobenzoic acid

: 911847-22-8
(S)-(2-(methoxymethyl)pyrrolidin-1-yl)(3',4,4'-trimethoxybiphenyl-3-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / 16 h / Heating

2: Et₃N / CH₂Cl₂ / 15 h / 20 °C

3: NaH / tetrahydrofuran / 0 - 20 °C

4: 96 percent / K₂CO₃; Pd(OAc)2; Ph₃P / K₂CO₃ / propan-1-ol / Heating

With palladium diacetate; thionyl chloride; sodium hydride; potassium carbonate; triethylamine; triphenylphosphine; potassium carbonate; In tetrahydrofuran; propan-1-ol; dichloromethane; 4: Suzuki reaction;
DOI:10.1021/ol0615228