2786-00-7

Usage

Uses

Used in Pharmaceutical Industry:
5-IODO-2-METHOXYBENZOIC ACID is used as a chemical intermediate for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows it to be a versatile building block in the development of new drugs and therapeutic agents.
Used in Dye and Pigment Industry:
5-IODO-2-METHOXYBENZOIC ACID is used as a key component in the production of certain dyes and pigments. Its chemical properties contribute to the color and stability of these products, making it valuable in the manufacturing process.
Used in Medicinal Research:
5-IODO-2-METHOXYBENZOIC ACID is used as a subject of interest for medicinal and pharmaceutical research due to its potential biological activities. Its antimicrobial and anti-inflammatory properties are being studied for their potential applications in the development of new treatments and therapies.
Used in Organic Synthesis:
5-IODO-2-METHOXYBENZOIC ACID is used as a reagent in organic synthesis, allowing for the creation of a wide range of organic compounds. Its unique structure and functional groups make it a valuable component in various chemical reactions and processes.

Upstream product

• 109-72-8 n-butyllithium 
• 60-29-7 diethyl ether 
• 696-62-8 para-iodoanisole 
• 42298-41-9 5-iodo-2-methoxy-benzaldehyde 
• 579-75-9 2-Methoxybenzoic acid 
• 82357-61-7 ((2-methoxybenzoyl)oxy)silver 
• 119-30-2 2-hydroxy-5-iodobenzoic acid 
• 74-88-4 methyl iodide 
• 40757-09-3 methyl 2-methoxy-5-iodobenzoate 
• 124-38-9 carbon dioxide 

Downstream Products

• 115655-34-0 [125I]-Iodopride 
• 115860-70-3 (R)-N-<(1-ethyl-2-pyrrolidinyl)methyl>-5-iodo-2-methoxybenzamide 
• 40757-09-3 methyl 2-methoxy-5-iodobenzoate 
• 58765-12-1 2-hydroxy-5-mercaptobenzoic acid 
• 80530-56-9 5-mercapto-2-methoxybenzoic acid 
• 1354412-93-3 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxybenzoic acid hydrochloride 
• 1354412-91-1 isopropyl 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-methoxy-benzoate 
• 1354412-90-0 isopropyl 5-iodo-2-methoxybenzoate 
• 1346563-48-1 C₂₆H₂₃F₂N₅O₅ 
• 1346567-55-2 C₂₂H₂₇NO₄ 
• 1346563-44-7 C₁₉H₁₇F₂N₅O₅ 
• 1346567-53-0 C₁₈H₂₁NO₃ 
• 1346565-79-4 C₃₀H₂₉N₇O₆S 

Relevant academic research and scientific papers

Transition-Metal-Free Decarboxylative Iodination: New Routes for Decarboxylative Oxidative Cross-Couplings

Constructing products of high synthetic value from inexpensive and abundant starting materials is of great importance. Aryl iodides are essential building blocks for the synthesis of functional molecules, and efficient methods for their synthesis from chemical feedstocks are highly sought after. Here we report a low-cost decarboxylative iodination that occurs simply from readily available benzoic acids and I2. The reaction is scalable and the scope and robustness of the reaction is thoroughly examined. Mechanistic studies suggest that this reaction does not proceed via a radical mechanism, which is in contrast to classical Hunsdiecker-type decarboxylative halogenations. In addition, DFT studies allow comparisons to be made between our procedure and current transition-metal-catalyzed decarboxylations. The utility of this procedure is demonstrated in its application to oxidative cross-couplings of aromatics via decarboxylative/C-H or double decarboxylative activations that use I2 as the terminal oxidant. This strategy allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other advantages over existing decarboxylative oxidative couplings, as stoichiometric transition metals are avoided.

Copper-catalyzed formal c-h carboxylation of aromatic compounds with carbon dioxide through arylaluminum intermediates

The C-H bond carboxylation of various aromatic compounds with CO2 was achieved by the deprotonative alumination with a mixed alkyl amido lithium aluminate compound iBu3Al(TMP)Li followed by the NHC-copper-catalyzed carboxylation of the resulting arylaluminum species, which afforded the corresponding carboxylation products in high yield and high selectivity. In addition to benzene derivatives, heteroarenes such as benzofuran, benzothiophene, and indole derivatives are also suitable substrates. Functional groups such as Cl, Br, I, vinyl, amide, and CN could survive the reaction conditions. Some key reaction intermediates such as the copper aryl and isobutyl complexes and their carboxylation products were isolated and structurally characterized by X-ray crystallographic analyses, thus offering important information on the reaction mechanism.

Gold(I)-catalyzed iodination of arenes

A wide variety of electron-rich arenes were efficiently converted into the corresponding iodinated compounds via a gold(I)-catalyzed reaction under mild conditions. Georg Thieme Verlag Stuttgart. New York.

TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE

Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables RA, RB and RC are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D2-like dopamine receptors

Benzamide derivatives as radiotracers have played an important role in diagnosing malfunction in dopaminergic neurotransmission. A variety of halogenated and two unsubstituted benzamide derivatives were synthesised and their in vitro affinities to dopaminergic, serotonergic and adrenergic receptors and their lipophilicities were determined. As references IBZM (3), raclopride (4) and FLB457 (5) were tested as well. The two iodinated compounds NAE (27) and NADE (28) displayed Ki values of 0.68 and 14 nM for the D2 receptor. The well-established radiotracers FP (1) and DMFP (2) showed affinities in the same range as did the brominated compounds NABrE (29) and NABrDE (30). The log D7.4 values of 2.91 for NAE (27) and of 2.81 for NADE (28) are in the range of those found for IBZM (3), FP (1) and DMFP (2). These facts allow to expect good properties for the two iodinated compounds NAE (27) and NADE (28) regarding in vivo imaging with SPECT.

Solvent-free iodination of arenes using iodine-silver nitrate combination

A simple and environmentally safe general method of iodination of aromatic substrates under sovent-free conditions using the I2/AgNO3 combination in a solid state is reported. Both activated and deactivated aromatic compounds afford the respective aryl iodides in generally high yields (80-90%). Copyright Taylor & Francis Group, LLC.

BIS-ARYL KINASE INHIBITORS AND METHOD

Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

The enantioselective Birch-Cope sequence for the synthesis of carbocyclic quaternary stereocenters. Application to the synthesis of (+)-mesembrine

A synthetic technique for generating carbocyclic quaternary stereocenters with exceptionally high levels of enantioselectivity is described. A sequence of three reactions, enantioselective Birch reduction-allylation, enol ether hydrolysis, and Cope rearrangement, is used to stereoselectively generate chiral quaternary centers on a 2-cyclohexen-1-one ring. The products of the sequence are 4,4-disubstituted-2-carboxamide-2-cyclohexen-1-one structures which are versatile intermediates in complex natural product synthesis. An application of the sequence to the synthesis of (+)-mesembrine illustrates the utility of these intermediates.