Regorafenib Impurity 6

Base Information

Chemical Name:Regorafenib Impurity 6
CAS No.:1187945-05-6
Molecular Formula:C₂₀H₁₂ClF₄N₃O₄
Molecular Weight:469.78
Hs Code.:
Mol file:1187945-05-6.mol

Synonyms:4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid

Suppliers and Price of Regorafenib Impurity 6

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinicAcid
5mg
$ 80.00

Total 12 raw suppliers

Chemical Property of Regorafenib Impurity 6

Chemical Property:

Boiling Point:499.8±45.0 °C(Predicted)
PKA:0.97±0.50(Predicted)
Density:1.587±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-(4-(3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic Acid -- Regorafenib Impurity 6

Technology Process of Regorafenib Impurity 6

There total 7 articles about Regorafenib Impurity 6 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1187945-02-3
tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

: 1187945-05-6
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

: 1020173-15-2
tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate

: 1187945-05-6
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 16 h / 20 °C

2: trifluoroacetic acid; triethylsilane / dichloromethane / 16 h / 50 °C

With triethylsilane; trifluoroacetic acid; In dichloromethane;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1187945-05-6
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / Reflux

2.1: pyridine / dichloromethane / 16 h / -40 - 50 °C

3.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

3.2: 1 h / 100 °C

4.1: dichloromethane / 16 h / 20 °C

5.1: trifluoroacetic acid; triethylsilane / dichloromethane / 16 h / 50 °C

With pyridine; triethylsilane; thionyl chloride; potassium tert-butylate; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;