tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Base Information

Chemical Name:tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate
CAS No.:1187945-02-3
Molecular Formula:C₂₄H₂₀ClF₄N₃O₄
Molecular Weight:525.887
Hs Code.:

Synonyms:tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

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Chemical Property of tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

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Technology Process of tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

There total 5 articles about tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1020173-15-2
tert-butyl 4-(4-amino-3-fluorophenoxy)picolinate

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1187945-02-3
tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Guidance literature:: In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1187945-02-3
tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / Reflux

2.1: pyridine / dichloromethane / 16 h / -40 - 50 °C

3.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

3.2: 1 h / 100 °C

4.1: dichloromethane / 16 h / 20 °C

With pyridine; thionyl chloride; potassium tert-butylate; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 220000-86-2
tert-butyl 4-chloropyridine-2-carboxylate

: 1187945-02-3
tert-butyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

1.2: 1 h / 100 °C

2.1: dichloromethane / 16 h / 20 °C

With potassium tert-butylate; In dichloromethane; N,N-dimethyl acetamide;