methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Base Information

Chemical Name:methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate
CAS No.:1333489-02-3
Molecular Formula:C₂₁H₁₄ClF₄N₃O₄
Molecular Weight:483.806
Hs Code.:

Synonyms:methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

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Chemical Property of methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Chemical Property:

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Technology Process of methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

There total 6 articles about methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1187945-05-6
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid

: 1333489-02-3
methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Guidance literature:: With sulfuric acid; for 3h; Reflux;

Reference yield:

: 5470-22-4
4-chloropicolinic acid

: 1333489-02-3
methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 2 h / Reflux

2.1: pyridine / dichloromethane / 16 h / -40 - 50 °C

3.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

3.2: 1 h / 100 °C

4.1: dichloromethane / 16 h / 20 °C

5.1: trifluoroacetic acid; triethylsilane / dichloromethane / 16 h / 50 °C

6.1: sulfuric acid / 3 h / Reflux

With pyridine; triethylsilane; thionyl chloride; sulfuric acid; potassium tert-butylate; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;

Reference yield:

: 220000-86-2
tert-butyl 4-chloropyridine-2-carboxylate

: 1333489-02-3
methyl 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.5 h / 20 °C

1.2: 1 h / 100 °C

2.1: dichloromethane / 16 h / 20 °C

3.1: trifluoroacetic acid; triethylsilane / dichloromethane / 16 h / 50 °C

4.1: sulfuric acid / 3 h / Reflux

With triethylsilane; sulfuric acid; potassium tert-butylate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl acetamide;