(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Base Information

Chemical Name:(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile
CAS No.:1313758-39-2
Molecular Formula:C₁₄H₁₁F₃N₂OS
Molecular Weight:312.315
Hs Code.:

Synonyms:(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Suppliers and Price of (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

There total 3 articles about (R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 7677-24-9
trimethylsilyl cyanide

: 1313758-22-3
C₁₃H₁₀F₃NOS

: 1313758-39-2
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; C₂₉H₃₀F₆N₄O₂; In toluene; at 25 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/ol201316z

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 313353-93-4
4-methoxy-N-(2,2,2-trifluoro-1-(thiophen-2-yl)ethylidene)aniline

: 1313758-39-2
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Guidance literature:: With 1-(3,5-Bis-trifluoromethyl-phenyl)-3-[(S)-((1S,2S,4S,5R)-5-ethyl-1-aza-bicyclo[2.2.2]oct-2-yl)-(6-methoxy-quinolin-4-yl)-methyl]-urea; In toluene; at 20 ℃; for 24h; enantioselective reaction; Sealed tube;
DOI:10.1002/cjoc.201800001

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 313353-93-4
4-methoxy-N-(2,2,2-trifluoro-1-(thiophen-2-yl)ethylidene)aniline

: 1313758-39-2
(R)-3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

: 3,3,3-trifluoro-2-((4-methoxyphenyl)amino)-2-(thiophen-2-yl)propanenitrile

Guidance literature:: With (S)-1-[3,5-bis(trifluoromethyl)phenyl]-3-(1-(diphenylphosphaneyl)-3,3-dimethylbutan-2-yl)thiourea; acrylic acid methyl ester; In dichloromethane; at -20 ℃; for 24h; Overall yield = 86 percent; enantioselective reaction;
DOI:10.1039/c9cc09151c