(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

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Chemical Name:(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate
CAS No.:1344706-82-6
Molecular Formula:C₂₆H₂₄F₃N₅O₅
Molecular Weight:543.502
Hs Code.:

Synonyms:(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

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Chemical Property of (R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

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Technology Process of (R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

There total 5 articles about (R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.9%

: 6456-74-2
Glycine tert-butyl ester

: 1344708-45-7
(R/S)-2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetic acid

: 1344706-82-6
(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; for 0.333333h;

Reference yield:

: 302912-31-8
ethyl-4-cyanobenzoylformate

: 1344706-82-6
(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 6 h / 70 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

3.2: 2 h / 140 °C

3.3: 0.5 h

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h

With 4-methyl-morpholine; methanol; sodium tetrahydroborate; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 847227-46-7
ethyl 2-(4-cyanophenyl)-2-hydroxyacetate

: 1344706-82-6
(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 6 h / 70 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

2.2: 2 h / 140 °C

2.3: 0.5 h

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h

With 4-methyl-morpholine; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;