(R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

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Chemical Name:(R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid
CAS No.:1344706-86-0
Molecular Formula:C₂₂H₁₆F₃N₅O₅
Molecular Weight:487.395
Hs Code.:

Synonyms:(R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

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Chemical Property of (R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

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Technology Process of (R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

There total 6 articles about (R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.2%

: 1344706-82-6
(R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate

: 1344706-86-0
(R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

Guidance literature:: (R/S)-tert-butyl 2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetate; With lithium hydroxide; In tetrahydrofuran; methanol; for 0.666667h;

With hydrogenchloride; In tetrahydrofuran; methanol; water; pH=4 - 5;

Reference yield:

: 302912-31-8
ethyl-4-cyanobenzoylformate

: 1344706-86-0
(R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

2.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 6 h / 70 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

3.2: 2 h / 140 °C

3.3: 0.5 h

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h

5.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h

6.1: lithium hydroxide / tetrahydrofuran; methanol / 0.67 h

6.2: pH 4 - 5

With 4-methyl-morpholine; methanol; sodium tetrahydroborate; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 847227-46-7
ethyl 2-(4-cyanophenyl)-2-hydroxyacetate

: 1344706-86-0
(R/S)-2-(2-hydroxy-2-(4-(5-(1-phenyl-5-(trifluoromethyl)-1H-pyrazol-4-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamido)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / isopropyl alcohol / 6 h / 70 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

2.2: 2 h / 140 °C

2.3: 0.5 h

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.5 h

4.1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 0.33 h

5.1: lithium hydroxide / tetrahydrofuran; methanol / 0.67 h

5.2: pH 4 - 5

With 4-methyl-morpholine; hydroxylamine hydrochloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; HATU; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol;