C₂₈H₂₈ClNO₃

Base Information

Chemical Name:C₂₈H₂₈ClNO₃
CAS No.:1359022-74-4
Molecular Formula:C₂₈H₂₈ClNO₃
Molecular Weight:461.988
Hs Code.:

C<sub>28</sub>H<sub>28</sub>ClNO<sub>3</sub>

Synonyms:C₂₈H₂₈ClNO₃

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Chemical Property of C₂₈H₂₈ClNO₃

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Technology Process of C₂₈H₂₈ClNO₃

There total 20 articles about C₂₈H₂₈ClNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 27374-25-0
[(1-Ethoxycyclopropyl)oxy]trimethylsilane

: 1359022-62-0
phenyl 6-(benzyloxy)-3-chloro-2-methyl-4-(pyrrolidin-2-yl)benzoate

: 1359022-74-4
C₂₈H₂₈ClNO₃

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 55 ℃; for 3h; Molecular sieve;

Reference yield:

: 877149-05-8
4-bromo-2-methoxy-6-methyl-benzonitrile

: 1359022-74-4
C₂₈H₂₈ClNO₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -78 - 20 °C

1.2: 1 h / 20 °C

2.1: sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene / water; tert-butyl alcohol / 0.5 h / 20 °C

2.2: pH 1

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

4.1: triethylamine / dmap / 1 h / 20 °C

5.1: N-chloro-succinimide / acetonitrile / 45 h / 60 °C

6.1: boron tribromide / dichloromethane / 0.75 h / -78 - 0 °C

6.2: 0.17 h / 20 °C

7.1: potassium carbonate / acetone / 20 °C

8.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -100 °C / Inert atmosphere

8.2: 2 h / -78 °C

9.1: methanol; sodium tetrahydroborate / 0.5 h / 0 - 20 °C

10.1: sodium cyanoborohydride; acetic acid / methanol / 3 h / 55 °C / Molecular sieve

With methanol; sodium chlorite; sodium tetrahydroborate; sodium dihydrogenphosphate; N-chloro-succinimide; n-butyllithium; 2-methyl-but-2-ene; oxalyl dichloride; boron tribromide; diisobutylaluminium hydride; sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; dmap; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 877149-08-1
4-bromo-2-methoxy-6-methyl-benzoic acid

: 1359022-74-4
C₂₈H₂₈ClNO₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2.1: triethylamine / dmap / 1 h / 20 °C

3.1: boron tribromide / dichloromethane / 0.58 h / -78 - 0 °C

3.2: 0.33 h / 20 °C

4.1: potassium carbonate / acetone / 20 °C

5.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water; toluene / 2 h / 90 °C / Inert atmosphere

6.1: hydrogen / palladium on activated carbon / methanol / 2 h / 20 °C / 760.05 Torr

7.1: potassium carbonate / acetone / 20 °C

8.1: N-chloro-succinimide / acetonitrile / 18 h / 60 °C

9.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

10.1: sodium cyanoborohydride; acetic acid / methanol / 3 h / 55 °C / Molecular sieve

With hydrogenchloride; N-chloro-succinimide; oxalyl dichloride; hydrogen; boron tribromide; sodium cyanoborohydride; sodium carbonate; potassium carbonate; acetic acid; triethylamine; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated carbon; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane; water; acetone; toluene; acetonitrile;