(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

Base Information

Chemical Name:(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride
CAS No.:133534-48-2
Molecular Formula:C₂₀H₂₄N₂O₃*ClH
Molecular Weight:376.883
Hs Code.:

Synonyms:(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

Suppliers and Price of (RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

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Chemical Property of (RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

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Technology Process of (RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

There total 8 articles about (RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.3%

: 133534-75-5,133534-76-6
(RS,RS) ethyl<(1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl)ethyl>imidoate hydrochloride

: 107-15-3,85404-18-8
ethylenediamine

: 133534-48-2
(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

Guidance literature:: In ethanol; at 0 - 10 ℃; for 4h;
DOI:10.1016/0223-5234(90)90195-9

Reference yield:

: 94-71-3
2-Ethoxyphenol

: 133534-48-2
(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 57.2 percent / 85percent aq. KOH / 7 h / 70 °C

2: 100 percent / 98percent H₂SO₄ / 40 h / Ambient temperature

3: 100 percent / NaH / dimethylformamide / 1 h / 10 °C

4: 77.4 percent / 30percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

5: 87.6 percent / pyridine, trifluoroacetic anhydride / dioxane / 3 h / Ambient temperature

6: 76.4 percent / HCl (gas) / diethyl ether / 7 h / Ambient temperature

7: 56.3 percent / ethanol / 4 h / 0 - 10 °C

With pyridine; hydrogenchloride; potassium hydroxide; ammonium hydroxide; sulfuric acid; sodium hydride; trifluoroacetic anhydride; In 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(90)90195-9

Reference yield:

: 133534-59-5,133534-60-8
(RS,RS) 2-hydroxy-3-(2-ethoxyphenoxy)-3-benzenepropanoic acid

: 133534-48-2
(RS,SR) 2-<1-methoxy-2-(2-ethoxyphenoxy)-2-phenyl>ethyl-4,5-dihydro-1H-imidazole hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / 98percent H₂SO₄ / 40 h / Ambient temperature

2: 100 percent / NaH / dimethylformamide / 1 h / 10 °C

3: 77.4 percent / 30percent NH₄OH / dimethylformamide / 36 h / Ambient temperature

4: 87.6 percent / pyridine, trifluoroacetic anhydride / dioxane / 3 h / Ambient temperature

5: 76.4 percent / HCl (gas) / diethyl ether / 7 h / Ambient temperature

6: 56.3 percent / ethanol / 4 h / 0 - 10 °C

With pyridine; hydrogenchloride; ammonium hydroxide; sulfuric acid; sodium hydride; trifluoroacetic anhydride; In 1,4-dioxane; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(90)90195-9