(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

Base Information

Chemical Name:(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide
CAS No.:444728-13-6
Molecular Formula:C₁₅H₁₅ClN₂OS
Molecular Weight:306.816
Hs Code.:

Synonyms:(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

Suppliers and Price of (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 9 raw suppliers

Chemical Property of (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

Chemical Property:

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetamide is an intermediate in the preparation of Clopidogrel(C587250) which is used as an antithrombotic.

Technology Process of (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

There total 1 articles about (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

: 444728-14-7
(+)-(1S)-camphor-10-sulfonic acid salt of (S)-2-(2-chlorophenyl)-(6,7-dihydro-4H-thieno[3,2-c]pyrid-5-yl)acetamide

: 444728-13-6
(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

Guidance literature:: With sodium hydrogencarbonate; In methanol; water; for 3.5h;

Reference yield: 73.0%

: 67-56-1
methanol

: 444728-13-6
(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

: 77-78-1
dimethyl sulfate

: 113665-84-2,94188-84-8
(S)-(+)-clopidogrel

Guidance literature:: methanol; dimethyl sulfate; With sulfuric acid; at 25 - 38 ℃; for 3h; Heating / reflux;

(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide; at 40 - 66 ℃; for 60h;

Reference yield:

: 67-56-1
methanol

: 444728-13-6
(+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide

: 113665-84-2,94188-84-8
(S)-(+)-clopidogrel

Guidance literature:: methanol; (+)-α-(4,5,6,7-tetrahydrothieno[3,2-c]-5-pyridyl)-α-2-chlorophenylacetamide; With benzenesulfonic acid; at 70 - 75 ℃; for 10 - 24h;

With sodium hydrogencarbonate; In methanol; dichloromethane; water; Product distribution / selectivity;