tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

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Chemical Name:tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate
CAS No.:1443792-24-2
Molecular Formula:C₃₂H₃₅N₃O₄S
Molecular Weight:557.714
Hs Code.:

Synonyms:tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

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Chemical Property of tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

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Technology Process of tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

There total 6 articles about tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1443792-20-8
tert-butyl (S)-3-(4-(5-bromopyrimidin-2-yl)phenyl)-2-(5-(tert-butyl)thiophene-2-carboxamido)propanoate

: 71597-85-8
(p-hydroxyphenyl)boronic acid

: 1443792-24-2
tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In tetrahydrofuran; water; acetonitrile; at 110 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: 16874-12-7,87553-74-0
Tyr(tBu)

: 1443792-24-2
tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: HATU; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 18 h

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 100 °C / Inert atmosphere

4: sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 1 h / 120 °C / Microwave irradiation

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; tetrahydrofuran; acetonitrile / 0.75 h / 110 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydrogencarbonate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 29212-25-7
5-(tert-butyl)thiophene-2-carboxylic acid

: 1443792-24-2
tert-butyl (S)-2-(5-(tert-butyl)thiophene-2-carboxamido)-3-(4-(5-(4-hydroxyphenyl)pyrimidin-2-yl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1: HATU; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / 18 h

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 18 h / 100 °C / Inert atmosphere

4: sodium hydrogencarbonate / water; tetrahydrofuran; acetonitrile / 1 h / 120 °C / Microwave irradiation

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; tetrahydrofuran; acetonitrile / 0.75 h / 110 °C / Microwave irradiation

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; sodium hydrogencarbonate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;