2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol

Base Information

• Chemical Name: 2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol
• CAS No.: 1170701-65-1
• Molecular Formula: C₂₄H₂₃BrClNO
• Molecular Weight: 456.81
• Mol file: 1170701-65-1.mol

Synonyms:2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol

Chemical Property of 2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol

Chemical Property:

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Technology Process of 2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol

There total 1 articles about 2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-2-(2-bromostyryl)-4-chlorophenyl acetate (1000890-04-9) + (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2) → 2-((3S,4S)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol (1170701-65-1) + 2-((3R,4R)-4-(2-bromophenyl)-1-((R)-1-phenylethyl)pyrrolidin-3-yl)-4-chlorophenol (1170701-67-3)

Guidance literature:

(E)-2-(2-bromostyryl)-4-chlorophenyl acetate; (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine; With trifluoroacetic acid; In toluene; at 20 ℃; for 2h;

With water; potassium hydroxide; In methanol; at 20 ℃; for 0.5h;

With hydrogenchloride; In methanol; water;

upstream raw materials:

(E)-2-(2-bromostyryl)-4-chlorophenyl acetate

(R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine