(R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

Base Information

• Chemical Name: (R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine
• CAS No.: 133407-38-2
• Molecular Formula: C14H25NOSi
• Molecular Weight: 251.444
• Hs Code.: 2931900090
• European Community (EC) Number: 681-102-8
• DSSTox Substance ID: DTXSID50928109
• Nikkaji Number: J1.034.162K
• Mol file: 133407-38-2.mol

Synonyms:133407-38-2;(R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine;(R)-(+)-N-Methoxymethyl-N-(trimethylsilyl)methyl-1-phenylethylamine;(R)-Methoxymethyl-(1-phenyl-ethyl)-trimethylsilanylmethyl-amine;(1R)-N-(methoxymethyl)-1-phenyl-N-(trimethylsilylmethyl)ethanamine;C14H25NOSi;SCHEMBL1773267;DTXSID50928109;(R)-N-Methoxymethyl-N-(1-phenylethyl)-N-trimethylsilylmethylamine;AMY31950;MFCD06798959;(R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethan-1-amine;AKOS016844233;CS-W006291;A806611;J-502264;(methoxymethyl)[(1R)-1-phenylethyl][(trimethylsilyl)methyl]amine;(R)-(+)-N-Methoxymethyl-N-trimethylsilylmethyl-1-phenylethylamine;N-(Methoxymethyl)-1-phenyl-N-[(trimethylsilyl)methyl]ethan-1-amine;(1R)-N-(methoxymethyl)-1-phenyl-N-[(trimethylsilyl)-methyl]ethanamine;N-(R)-|A-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine;(alphaR)-alpha-Methyl-N-(methoxymethyl)-N-(trimethylsilylmethyl)benzenemethaneamine

Chemical Property of (R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

Chemical Property:

• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.4930
• Boiling Point: 82-84°C 0,2mm
• PKA: 7.37±0.50(Predicted)
• Flash Point: 82-84°C/0.2mm
• PSA: 12.47000
• Density: 0,926 g/cm3
• LogP: 3.94920
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Sensitive.: Moisture Sensitive
• Water Solubility.: Not miscible or difficult to mix in water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 251.170540955
• Heavy Atom Count: 17
• Complexity: 209

Purity/Quality:

99% ^*data from raw suppliers

(R)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)N(COC)C[Si](C)(C)C
• Isomeric SMILES: C[C@H](C1=CC=CC=C1)N(COC)C[Si](C)(C)C
• Uses: (R)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine is used in preparation of (indazol-4-yl)hexahydropyrrolopyrrolones as sodium channel blockers useful for treating pain.

Technology Process of (R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

There total 4 articles about (R)-N-(methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

→ (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2)

Guidance literature:

Reference yield: 64.0%

methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-(+)-N-1-phenylethyl-N-trimethylsilylmethylamine (104942-85-0) → (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2)

Guidance literature:

With potassium carbonate; In water; at 0 ℃; for 2.5h;

DOI:10.1039/a803693d

Reference yield:

methanol (67-56-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + (R)-1-phenyl-ethyl-amine (3886-69-9) + Chloromethyltrimethylsilane (2344-80-1) → (R)-N-(1-phenylethyl)-N-(methoxymethyl)-N-(trimethylsilylmethyl)amine (133407-38-2)

Guidance literature:

(R)-1-phenyl-ethyl-amine; Chloromethyltrimethylsilane; In dimethyl sulfoxide; at 100 ℃; for 12h; Inert atmosphere; Large scale;

methanol; formaldehyd; With potassium carbonate; at 10 ℃; for 2h; Large scale;

DOI:10.1021/op049889k

upstream raw materials:

methanol

formaldehyd

(R)-(+)-N-1-phenylethyl-N-trimethylsilylmethylamine

(R)-1-phenyl-ethyl-amine

Downstream raw materials:

methyl (3aS,6aR)-5-[(1R)-1-phenylethyl]tetrahydro-1H-thieno[3,4-c]pyrrole-3a(3H)-carboxylate 2,2-dioxide

3-(R)-(2-Hydroxy-6-methoxy)phenyl-4-(S)-hydroxymethyl-N-(R)-α-methylbenzyl-pyrrolidine

Refernces

• 1、 Gerlach, Kai,Hoffmann,Wartchow. "Non-stabilized azomethine ylides in [3 + 2] cycloadditions. Pyrrolidinylfuranones from (5S)-5-menthyloxy-4-vinylfuran-2(5H)-one". . p. 3867 - 3872. Retrieved 2007/10/03.
• 2、 -. "Chiral synthesis for producing 1-azabicyclo[2.2.1] heptane-3-carboxylates". . . Retrieved 2008/06/13.