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133407-38-2

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  • N-(R)-α-methylbenzyl-N-(methoxymethyl)-N-((trimethylsilyl)methyl)amine

    Cas No: 133407-38-2

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133407-38-2 Usage

Uses

(R)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine is used in preparation of (indazol-4-yl)hexahydropyrrolopyrrolones as sodium channel blockers useful for treating pain.

Check Digit Verification of cas no

The CAS Registry Mumber 133407-38-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,4,0 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 133407-38:
(8*1)+(7*3)+(6*3)+(5*4)+(4*0)+(3*7)+(2*3)+(1*8)=102
102 % 10 = 2
So 133407-38-2 is a valid CAS Registry Number.
InChI:InChI=1/C14H25NOSi/c1-13(14-9-7-6-8-10-14)15(11-16-2)12-17(3,4)5/h6-10,13H,11-12H2,1-5H3/t13-/m1/s1

133407-38-2 Well-known Company Product Price

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  • Alfa Aesar

  • (L19413)  (R)-(+)-N-Methoxymethyl-N-(trimethylsilyl)methyl-1-phenylethylamine, tech. 85%   

  • 133407-38-2

  • 1g

  • 488.0CNY

  • Detail
  • Alfa Aesar

  • (L19413)  (R)-(+)-N-Methoxymethyl-N-(trimethylsilyl)methyl-1-phenylethylamine, tech. 85%   

  • 133407-38-2

  • 5g

  • 1629.0CNY

  • Detail

133407-38-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name (R)-N-(Methoxymethyl)-1-phenyl-N-((trimethylsilyl)methyl)ethanamine

1.2 Other means of identification

Product number -
Other names (R)-(+)-N-Methoxymethyl-N-(trimethylsilyl)methyl-1-phenylethylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:133407-38-2 SDS

133407-38-2Relevant articles and documents

A scaleable synthesis of fiduxosin

Haight, Anthony R.,Bailey, Anne E.,Baker, William S.,Cain, Michael H.,Copp, Richard R.,Demattei, John A.,Ford, Kelley L.,Henry, Rodger F.,Hsu, Margaret C.,Keyes, Robert F.,King, Steven A.,McLaughlin, Maureen A.,Melcher, Laura M.,Nadler, William R.,Oliver, Patricia A.,Parekh, Shyamal I.,Patel, Hemant H.,Seif, Louis S.,Staeger, Mike A.,Wayne, Gregory S.,Wittenberger, Steven J.,Zhang, Weijiang

supporting information, p. 897 - 902 (2013/09/03)

Fiduxosin (1) has been under development at Abbott Laboratories for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies for preparation of an enantiomerically pure 3,4-cis-disubstituted pyrrolidine and a 2,3,5-trisubstituted thienopyrazine in a regiospecific manner. A [3+2] cycloaddition of an enantiopure azomethine ylide followed by a diastereoselective crystallization was employed to prepare the benzopyranopyrrolidine in high diastereomeric and enantiomeric purity. Conditions for reduction of an O-aryl lactone susceptible to epimerization were developed, and cyclization of the alcohol/phenol to the ether was accomplished in high yield. The thienopyrazine was prepared by condensation of methyl thioglycolate and a regiospecifically prepared 2-bromo-3-cyano-5-phenylpyrazine. Conditions for effective halogen substitutive deamination to prepare regiospecific trisubstituted pyrazines will be described.

Single and double diastereoselection in azomethine ylide cycloaddition reactions with unsaturated chiral bicyclic lactams

Fray,Meyers

, p. 3362 - 3374 (2007/10/03)

Double diastereoselectivity data were analyzed to provide insight into the structural features that influence π-facial selectivity in 1,3-dipolar cycloadditions of chiral and achiral azomethine ylides to chiral, unsaturated bicyclic lactams. Three major steric contributions to the differences in stability (ΔΔG(≠)) between competing cycloaddition transition states were identified. The first major set of steric interactions involve that between the dipoles and the substituents on the left hemisphere (R2) and concave faces of the bicyclic lactams. This effectively hindered both α- and β-approaches in the nonextended transition states. The second major steric interaction was provided by the nonbonded interactions (i) between the R1 angular substituent on the bicyclic lactam and the π-system of the dipole. This interaction was shown to be very significant, causing reversal in π-facial attack of chiral and achiral dipoles when the angular substituent is changed from phenyl or methyl to hydrogen. The high diastereoselectivity observed now opens a route to highly substituted chiral, nonracemic pyrrolidines.

A Synthesis of 1-Azabicycloheptane-3-carboxylic Acid Esters in Enantiomerically Pure Form

Cottrell, Ian F.,Hands, David,Kennedy, Derek J.,Paul, Kerensa J.,Wright, Stanley H. B.,Hoogsteen, Karst

, p. 1091 - 1097 (2007/10/02)

A novel synthesis of ethyl 1-azabicycloheptane-3-carboxylate via 1-benzylperhydropyranopyrrol-4-one and 1-benzyl-3-(2-bromoethyl)-4-ethoxycarbonylpyrrolidinium bromide is described.Modification of the method, by incorporation of a chiral substituted benzyl group on the nitrogen atom, has led to the first reported process for the preparation of these esters in enantiomerically pure form.The absolute configuration of the bicyclic esters was deduced by X-ray crystallography of an intermediate, 2-perhydropyranopyrrole-4-one.

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