tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate

Base Information

• Chemical Name: tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate
• CAS No.: 1179805-07-2
• Molecular Formula: C₂₂H₂₇NO₂
• Molecular Weight: 337.462
• Mol file: 1179805-07-2.mol

Synonyms:tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate

Chemical Property of tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate

There total 1 articles about tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-benzylbenzaldehyde (32832-95-4) + 2-amino-isobutyric acid tert-butyl ester hydrochloride (84758-81-6) → tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate (1179805-07-2)

Guidance literature:

With triethylamine; In 1,1-dichloroethane; at 20 ℃; Reflux;

Reference yield: 88.0%

tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate (1179805-07-2) → tert-butyl 2-(2-benzylbenzylamino)-2-methylpropionate (1179804-51-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; under 3750.38 Torr;

Reference yield:

tert-butyl 2-{[1-(2-benzylphenyl)methylidene]amino}-2-methylpropionate (1179805-07-2) → 1-(2-benzylbenzyl)-3-(3-ethylphenyl)-5,5-dimethylimidazolidine-2,4-dione (1179802-79-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 3750.38 Torr

2: acetonitrile / 20 °C

3: hydrogenchloride; water / acetonitrile / 3 h / 20 °C

With hydrogenchloride; water; hydrogen; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;

upstream raw materials:

2-benzylbenzaldehyde

2-amino-isobutyric acid tert-butyl ester hydrochloride

Downstream raw materials:

1-(2-benzylbenzyl)-3-(3-ethylphenyl)-5,5-dimethylimidazolidine-2,4-dione

tert-butyl 2-(2-benzylbenzylamino)-2-methylpropionate

4-[3-(2-benzylbenzyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-trifluoromethylbenzonitrile