Technology Process of Quinazoline, 7-bromo-2,5-dichloro-8-methoxy-
There total 7 articles about Quinazoline, 7-bromo-2,5-dichloro-8-methoxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 16h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogenchloride; iron; acetic acid / ethanol / 0.33 h / 0 °C / Heating / reflux
2.1: 1-methyl-pyrrolidin-2-one / ammonium acetate / 0.75 - 1 h / 160 °C
3.1: trichlorophosphate / 1.35 h / 0 - 145 °C / Neat (no solvent)
4.1: boron tribromide / dichloromethane / 22 h / -10 - 20 °C
4.2: 1 h / 0 °C
5.1: N-chloro-succinimide / chloroform / 2 h / 40 °C
6.1: N-Bromosuccinimide / chloroform
7.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; N-chloro-succinimide; N-Bromosuccinimide; boron tribromide; iron; potassium carbonate; acetic acid; trichlorophosphate;
ammonium acetate;
In
ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1-methyl-pyrrolidin-2-one / ammonium acetate / 0.75 - 1 h / 160 °C
2.1: trichlorophosphate / 1.35 h / 0 - 145 °C / Neat (no solvent)
3.1: boron tribromide / dichloromethane / 22 h / -10 - 20 °C
3.2: 1 h / 0 °C
4.1: N-chloro-succinimide / chloroform / 2 h / 40 °C
5.1: N-Bromosuccinimide / chloroform
6.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C
With
1-methyl-pyrrolidin-2-one; N-chloro-succinimide; N-Bromosuccinimide; boron tribromide; potassium carbonate; trichlorophosphate;
ammonium acetate;
In
dichloromethane; chloroform; N,N-dimethyl-formamide;
