3-BROMOBENZYLZINC BROMIDE

Base Information

• Chemical Name: 3-BROMOBENZYLZINC BROMIDE
• CAS No.: 307496-31-7
• Molecular Formula: C₇H₆Br₂Zn
• Molecular Weight: 315.323
• Mol file: 307496-31-7.mol

Synonyms:3-BROMOBENZYLZINC BROMIDE;3-BROMOBENZYLZINC BROMIDE 0.5M &;3-bromobenzylzinc bromide solution

Chemical Property of 3-BROMOBENZYLZINC BROMIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 0.00000
• Density: g/cm³
• LogP: 3.60790
• Sensitive.: Air Sensitive
• Water Solubility.: Reacts with water.

Purity/Quality:

99% ^*data from raw suppliers

3-Bromobenzylzincbromide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,Xn
• Statements: 14-19-22-36/38
• Safety Statements: 16-26-33-36

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is employed as a intermediate for pharmaceutical.

Technology Process of 3-BROMOBENZYLZINC BROMIDE

There total 1 articles about 3-BROMOBENZYLZINC BROMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-bromobenzyl bromide (823-78-9) + zinc (7440-66-6) → (3-bromobenzyl)zinc(II) bromide (307496-31-7)

Guidance literature:

In tetrahydrofuran; for 0.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2014.05.088

Reference yield: 54.0%

2,6-dichloro-5-methylpyrimidine (1780-31-0) + (3-bromobenzyl)zinc(II) bromide (307496-31-7) → 4-(3-bromobenzyl)-2-chloro-5-methylpyrimidine (1571031-49-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 50 ℃; for 18h; Inert atmosphere;

Reference yield: 38.0%

2-chloropropionyl chloride (7623-09-8) + (3-bromobenzyl)zinc(II) bromide (307496-31-7) → 1-(3-bromophenyl)-3-chlorobutan-2-one (1570043-37-6)

Guidance literature:

(3-bromobenzyl)zinc(II) bromide; With copper(I) cyanide di(lithium chloride); In N,N-dimethyl-formamide; toluene; at 20 ℃; for 0.333333h;

2-chloropropionyl chloride; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; toluene; for 0.75h;

upstream raw materials:

meta-bromobenzyl bromide

zinc

Downstream raw materials:

3-bromo-1-(3-bromophenyl)butan-2-one

ethyl 4-(3-bromobenzyl)-5-methylthiazole-2-carboxylate

4-(3-bromobenzyl)-5-methylthiazole-2-carboxylic acid

5-(4-(3-bromobenzyl)-5-methylthiazol-2-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Refernces