2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 473918-96-6
• Molecular Formula: C₁₉H₂₃IO₃Si
• Molecular Weight: 454.38
• Mol file: 473918-96-6.mol

Synonyms:2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property of 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester

There total 2 articles about 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxy-3-iodo-benzaldehyde (23602-64-4) → 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester (473918-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate

2: manganese(IV) oxide; sodium cyanide; acetic acid / methanol

3: titanium(IV) isopropoxide

With titanium(IV) isopropylate; sodium cyanide; manganese(IV) oxide; potassium carbonate; acetic acid; In methanol;

DOI:10.1021/ol026694t

Reference yield:

2-benzyloxy-3-iodo-benzaldehyde (473918-95-5) → 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester (473918-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1: manganese(IV) oxide; sodium cyanide; acetic acid / methanol

2: titanium(IV) isopropoxide

With titanium(IV) isopropylate; sodium cyanide; manganese(IV) oxide; acetic acid; In methanol;

DOI:10.1021/ol026694t

Reference yield: 87.0%

N-carbobenzyloxy-4-iodo-indole-3-carboxaldehyde (473918-94-4) + 2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester (473918-96-6) → 4-[2-benzyloxy-3-(2-trimethylsilanyl-ethoxycarbonyl)-phenyl]-3-formyl-indole-1-carboxylic acid benzyl ester (473918-97-7)

Guidance literature:

2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester; With isopropylmagnesium chloride; In tetrahydrofuran; at -30 ℃;

With zinc dibromide; In tetrahydrofuran; at -78 - 20 ℃;

N-carbobenzyloxy-4-iodo-indole-3-carboxaldehyde; bis(tri-t-butylphosphine)palladium⁽⁰⁾; at 20 ℃; Further stages.;

DOI:10.1021/ol026694t

upstream raw materials:

2-hydroxy-3-iodo-benzaldehyde

2-benzyloxy-3-iodo-benzaldehyde

Downstream raw materials:

4-[2-benzyloxy-3-(2-trimethylsilanyl-ethoxycarbonyl)-phenyl]-3-formyl-indole-1-carboxylic acid benzyl ester