2-Hydroxy-3-iodobenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-3-iodobenzaldehyde
• CAS No.: 23602-64-4
• Molecular Formula: C7H5 I O2
• Molecular Weight: 248.02
• DSSTox Substance ID: DTXSID90570060
• Nikkaji Number: J2.190.462G
• Wikidata: Q72484636
• Mol file: 23602-64-4.mol

Synonyms:2-Hydroxy-3-iodobenzaldehyde;23602-64-4;Benzaldehyde, 2-hydroxy-3-iodo-;3-iodo-2-hydroxybenzaldehyde;2-hydroxy-3-iodo-benzaldehyde;MFCD13180433;3-IODOSALICYLALDEHYDE;SCHEMBL172768;2-hydroxy-3-iodo benzaldehyde;3-iodo-2-hydroxy-benzaldehyde;DTXSID90570060;HWJJTWWMMHEEAK-UHFFFAOYSA-N;AMY37718;AKOS015889827;MB12368;AS-40361;SY108270;CS-0097727;A816794;W-206834

Chemical Property of 2-Hydroxy-3-iodobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.0985mmHg at 25°C
• Melting Point: 69-71oC
• Boiling Point: 216oC
• PKA: 6.72±0.10(Predicted)
• Flash Point: 84 ºC
• PSA: 37.30000
• Density: 2.039
• LogP: 1.80930
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 247.93343
• Heavy Atom Count: 10
• Complexity: 127

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-3-iodobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C(=C1)I)O)C=O
• Uses: 2-Hydroxy-3-iodobenzaldehyde is a useful reagent for organic synthesis and other chemical processes.

Technology Process of 2-Hydroxy-3-iodobenzaldehyde

There total 9 articles about 2-Hydroxy-3-iodobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-hydroxy-3-(trimethylsilyl)benzaldehyde (444095-29-8) → 2-hydroxy-3-iodo-benzaldehyde (23602-64-4)

Guidance literature:

With Iodine monochloride; In methanol; at 0 - 20 ℃; for 12.5h;

DOI:10.1055/s-2006-926462

Reference yield: 95.0%

7-iodo-2-trimethylsilylbenzofuran (848890-10-8) → 2-hydroxy-3-iodo-benzaldehyde (23602-64-4)

Guidance literature:

7-iodo-2-trimethylsilylbenzofuran; With ozone; In dichloromethane; at -78 ℃;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/jo0478914

Reference yield: 84.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Iodophenol (533-58-4) → 2-hydroxy-3-iodo-benzaldehyde (23602-64-4)

Guidance literature:

With triethylamine; magnesium chloride; In tetrahydrofuran; for 12h; Inert atmosphere; Reflux;

DOI:10.1039/c2ob25618e

upstream raw materials:

chloroform

2-Iodophenol

formaldehyd

7-iodo-2-trimethylsilylbenzofuran

Downstream raw materials:

2-benzyloxy-3-iodo-benzoic acid 2-trimethylsilanyl-ethyl ester

4-[2-benzyloxy-3-(2-trimethylsilanyl-ethoxycarbonyl)-phenyl]-3-formyl-indole-1-carboxylic acid benzyl ester