5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

Base Information

Chemical Name:5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde
CAS No.:1333147-69-5
Molecular Formula:C₁₄H₁₂BrNO₃
Molecular Weight:322.158
Hs Code.:

Synonyms:5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

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Chemical Property of 5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

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Technology Process of 5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

There total 7 articles about 5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1333147-66-2
3-(benzyloxy)-5,6-dibromo-1-methylpyridin-2(1H)-one

: 67242-59-5
N-methyl-N-(2-pyridyl)-formamide

: 1333147-69-5
5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

Guidance literature:: 3-(benzyloxy)-5,6-dibromo-1-methylpyridin-2(1H)-one; With isopropylmagnesium chloride; In tetrahydrofuran; at -78 ℃; for 0.25h; Inert atmosphere;

N-methyl-N-(2-pyridyl)-formamide; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 1333147-69-5
5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: iodine; potassium carbonate / water / 20 °C

2.1: potassium carbonate / methanol / 50 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

3.2: 1 h / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.1: potassium carbonate / methanol / 48 h / 20 °C

6.1: bromine / acetic acid / 20 °C

7.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

7.2: 20 °C

With bromine; iodine; isopropylmagnesium chloride; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 1333147-57-1
3-(benzyloxy)-6-iodo-2-[(4-methoxybenzyl)oxy]pyridine

: 1333147-69-5
5-(benzyloxy)-3-bromo-1-methyl-6-oxo-1,6-dihydropyridine-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

2.1: potassium carbonate / methanol / 48 h / 20 °C

3.1: bromine / acetic acid / 20 °C

4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere

4.2: 20 °C

With bromine; isopropylmagnesium chloride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; acetic acid;