N-Methyl-N-(2-pyridyl)formamide

Base Information

• Chemical Name: N-Methyl-N-(2-pyridyl)formamide
• CAS No.: 67242-59-5
• Molecular Formula: C7H8N2O
• Molecular Weight: 136.153
• Hs Code.: 2933399090
• European Community (EC) Number: 266-616-9
• DSSTox Substance ID: DTXSID50986426
• Nikkaji Number: J236.230I
• Wikidata: Q72496929
• Mol file: 67242-59-5.mol

Synonyms:67242-59-5;N-Methyl-N-(2-pyridyl)formamide;N-Methyl-N-(pyridin-2-yl)formamide;N-methyl-N-pyridin-2-ylformamide;Meyer's reagent;Formamide, N-methyl-N-2-pyridinyl-;EINECS 266-616-9;N-Methyl-N-(pyridine-2-yl)formamide;Meyer reagent;N-methyl-N-pyridin-2-yl-formamide;N-methyl-2-pyridyl formamide;SCHEMBL114270;N-methyl-N-2-pyridylformamide;Methyl(2-pyridinyl)formamide #;2-(N-Formylmethylamino)pyridine;DTXSID50986426;AMY19921;2-(N-Formyl-N-methylamino)pyridine;2-(N-Methyl-N-formylamino)pyridine;MFCD00006260;AKOS009156898;N-methyl-N-(pyridin-2-yl) formamide;CS-W016530;SB53133;N-Methyl-N-(2-pyridyl)formamide, 99%;AS-61823;FT-0641109;M1187;BENZOYLMETHYLTRIPHENYLPHOSPHONIUMCHLORIDE;A867312

Chemical Property of N-Methyl-N-(2-pyridyl)formamide

Chemical Property:

• Vapor Pressure: 0.0009mmHg at 25°C
• Refractive Index: n20/D 1.566(lit.)
• Boiling Point: 71-72 °C0.05 mm Hg(lit.)
• PKA: 4.28±0.10(Predicted)
• Flash Point: 229 °F
• PSA: 33.20000
• Density: 1.137 g/mL at 25 °C(lit.)
• LogP: 1.31010
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.063662883
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

97% ^*data from raw suppliers

N-Methyl-N-(pyridin-2-yl)formamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C=O)C1=CC=CC=N1
• Uses: N-Methyl-N-(pyridin-2-yl)formamide has been used as a reactant to prepare Grignard reagents. N-Methyl-N-(2-pyridyl)formamide has been used in the synthesis of 3-formyl-2-(4-methoxybenzyl)pyrazol-1-oxide.

Technology Process of N-Methyl-N-(2-pyridyl)formamide

There total 6 articles about N-Methyl-N-(2-pyridyl)formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(N-methylamino)pyridine (4597-87-9) + formic acid (64-18-6) → N-methyl-N-(2-pyridyl)-formamide (67242-59-5)

Guidance literature:

With acetic anhydride;

DOI:10.1016/S0040-4039(01)90243-6

Reference yield: 69.0%

2-(N-methylamino)pyridine (4597-87-9) + carbon dioxide (124-38-9,18923-20-1) → N-methyl-N-(2-pyridyl)-formamide (67242-59-5)

Guidance literature:

With Triethoxysilane; zinc; In neat (no solvent); at 120 ℃; for 24h; under 11251.1 Torr; Autoclave;

DOI:10.1002/cjoc.202000072

Reference yield:

2-(formylamino)pyridine (34813-97-3) + methyl iodide (74-88-4) → N-methyl-N-(2-pyridyl)-formamide (67242-59-5)

Guidance literature:

With sodium hydride;

DOI:10.1246/cl.1984.239

upstream raw materials:

2-(N-methylamino)pyridine

formic acid

2-(formylamino)pyridine

methyl iodide

Downstream raw materials:

5-phenyloxazole-2-carbaldehyde

o-tert-Butylsulfonylbenzaldehyde

2-(2-Methyl-propane-2-sulfonyl)-benzene-1,3-dicarbaldehyde

2-(N-methylamino)pyridine