1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Base Information

Chemical Name:1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate
CAS No.:455954-81-1
Molecular Formula:C₁₉H₂₄ClNO₄
Molecular Weight:365.857
Hs Code.:

Synonyms:1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

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Chemical Property of 1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

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Technology Process of 1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

There total 5 articles about 1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1679-18-1
4-Chlorophenylboronic acid

: 176525-98-7
1-(1,1-dimethylethyl) 3-ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}-1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

: 455954-81-1
1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; water; at 65 ℃; for 3h; Inert atmosphere;

Reference yield:

: 41276-30-6
C₉H₁₄O₃NC₆H₅

: 455954-81-1
1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethanol; H₂O / 20 °C / 2585.74 Torr

2: aq. NaHCO₃; NaCl / CHCl₃ / 60 °C

3: DIPEA / CH₂Cl₂ / -78 °C

4: Pd(dppf)Cl₂; aq. NaHCO₃ / ethanol / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium chloride; palladium on activated charcoal; In ethanol; dichloromethane; chloroform; water; 4: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.bmcl.2005.06.033

Reference yield:

: 67848-59-3
4-piperidone-3-carboxylic acid ethyl ester

: 455954-81-1
1-(tert-butyl) 3-ethyl 4-(4-chlorophenyl)-5,6-dihydropyridine-1,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NaHCO₃; NaCl / CHCl₃ / 60 °C

2: DIPEA / CH₂Cl₂ / -78 °C

3: Pd(dppf)Cl₂; aq. NaHCO₃ / ethanol / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; sodium chloride; In ethanol; dichloromethane; chloroform; 3: Suzuki-Miyaura cross-coupling;
DOI:10.1016/j.bmcl.2005.06.033