7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

Base Information

Chemical Name:7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin
CAS No.:1454574-95-8
Molecular Formula:C₂₉H₂₈N₂O₅
Molecular Weight:484.552
Hs Code.:

Synonyms:7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

Chemical Property:

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Technology Process of 7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

There total 2 articles about 7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10-benzyloxy-7-ethylcamptothecin

: 1454574-95-8
7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

Guidance literature:: With potassium borohydride; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.jfluchem.2013.10.016

Reference yield:

: 100-39-0
benzyl bromide

: 1454574-95-8
7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 0 - 50 °C

2: potassium borohydride / methanol / 4 h / 20 °C

With potassium borohydride; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.jfluchem.2013.10.016

Reference yield: 32.0%

: 1454574-95-8
7-ethyl-10-benzyloxy-(20S, 21S)-diolcamptothecin

: 1454575-12-2
7-ethyl-10-benzyloxy-(20S, 21S)-fluorcamptothecin

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -95 - 0 ℃; for 2.16667h; Inert atmosphere;
DOI:10.1016/j.jfluchem.2013.10.016