1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

Base Information

Chemical Name:1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one
CAS No.:162044-60-2
Molecular Formula:C₂₁H₂₂N₂O₅
Molecular Weight:382.416
Hs Code.:

Synonyms:1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

Suppliers and Price of 1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

There total 5 articles about 1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 90111-34-5
4-hydroxy-2-methoxybenzoic acid

: 162045-31-0
1-piperidin-4-yl-1,4-dihydro-2H-3,1-benzoxazin-2-one hydrochloride

: 162044-60-2
1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00568-X

Reference yield:

: 2150-47-2
methyl 2,4-dihydroxybenzoate

: 162044-60-2
1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 58 percent / K₂CO₃ / acetone

2: 96 percent / NaH / dimethylformamide

3: 86 percent / H₂, AcOH / Pd/C / methanol

4: 95 percent / aq. NaOH / methanol

5: 95 percent / EDC, HOBT, i-Pr₂NEt / dimethylformamide

With sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0960-894X(98)00568-X

Reference yield:

: 28478-45-7
methyl 4-benzyloxy-2-methoxybenzoate

: 162044-60-2
1-[1-(4-Hydroxy-2-methoxy-benzoyl)-piperidin-4-yl]-1,4-dihydro-benzo[d][1,3]oxazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / H₂, AcOH / Pd/C / methanol

2: 95 percent / aq. NaOH / methanol

3: 95 percent / EDC, HOBT, i-Pr₂NEt / dimethylformamide

With sodium hydroxide; hydrogen; benzotriazol-1-ol; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00568-X