28478-45-7

Upstream product

• 5427-29-2 methyl 2-hydroxy-4-benzyloxybenzoate 
• 74-88-4 methyl iodide 
• 100-44-7 benzyl chloride 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 100-39-0 benzyl bromide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 134937-16-9 C₃₂H₄₅N₂O₆PSi 
• 28478-46-8 methyl 4-hydroxy-2-methoxybenzoate 
• 85607-79-0 4-(benzyloxy)-2-methoxybenzoic acid 
• 28478-47-9 methyl 5-chloro-4-hydroxy-2-methoxybenzoate 
• 1346763-27-6 2-chloro-4-(hydroxymethyl)-5-methoxyphenol 
• 95420-71-6 4-<(dimethylcarbamoyl)thio>-2-methoxybenzoic acid methyl ester 
• 95420-30-7 4-<(dimethylamino)thioxomethoxy>-2-methoxybenzoic acid methyl ester 
• 95420-72-7 4-mercapto-2-methoxybenzoic acid 
• 194151-64-9 (R)-1-{1-[4-(1-{pyridin-4-yl}ethoxy)-5-fluoro-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one 
• 194151-34-3 (+/-)-1-{1-[4-(1-{piperidin-4-yl}ethoxy)-2-methoxybenzoyl]-piperidin-4-yl}-4H-3,1-benzoxazin-2(1H)-one 

Relevant academic research and scientific papers

COMPOUNDS AND THEIR USES AS MIF INHIBITORS

The present invention provides compounds of Formula I which can be used as macrophage migration inhibitory factor (MIF) inhibitors; methods for the production of the compounds of the invention; pharmaceutical compositions comprising the compounds of the i

COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR

This disclosure pertains to compounds, the preparation thereof, and the use of these compounds in the treatment of prostate cancer, including metastatic and/or castrate-resistant prostate cancer, in subjects in need thereof.

NEW BICYCLIC DERIVATIVES HAVING BETA2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

1 -HYDROXY-BENZOOXABOROLES AS ANTIPARASITIC AGENTS

Provided are compounds useful for controlling endoparasites both in animals and agriculture. Further provided are methods for controlling endoparasite infestations of an animal by administering an effective amount of a compound as described above, or a pharmaceutically acceptable salt thereof, to an animal, as well as formulations for controlling endoparasite infestations using the compounds described above or an acceptable salt thereof, and an acceptable carrier. The claimed compounds are described by the following Markush formula:A typical example for a compound according to above formula is: A typical example for a compound according to above formula is:

Piperidine-based heterocyclic oxalyl amides as potent p38α MAP kinase inhibitors

The design and synthesis of a new class of p38α MAP kinase inhibitors based on 4-fluorobenzylpiperidine heterocyclic oxalyl amides are described. Many of these compounds showed low-nanomolar activities in p38α enzymatic and cell-based cytokine TNFα produc

HETEROCYCLIC AMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS

A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with the activity of p38 kinase.

AMINO ALCOHOL DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USE OF THESE

The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independently hydrogen or lower alkyl; each of R4, R5 and R6 is independently hydrogen, halogen, lower alkyl or lower alkoxy; R7 is hydrogen or lower alkyl; R8 is hydrogen, halogen, lower alkyl, lower alkoxy, etc; R9 is -COR10, -A1-COR10, -O-A2-COR10, etc; Ar is optionally substituted phenyl or heteroaryl; and A is a bond, -OCH2-, etc, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF

The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3 R4, R5 and R6 are each hydrogen, halogen, lower alkyl or lower alkoxy; R7 and R8 are each hydrogen, halogen, lower alkyl, halo-lower alkyl, lower alkoxy, cycloalkyl, aryl, heteroaryl, cyano, a hydroxyl group, lower acyl, carboxy or the like; R9 is -C(O)-R10, -A1-C(O)-R10, -O-A2-C(O)-R10 or a tetrazol-5-yl group, which exhibit potent and selective β3-adrenoceptor stimulating activities. The present invention also provides pharmaceutical compositions containing said compound, and uses thereof.

Inhibitors of p38-a kinase

The invention is directed to methods for treating conditions mediated by by P38α kinase using compounds of the formula wherein Ar1and Ph are limited to specific embodiments or wherein the compound of formula (3) is a compound set forth in FIGS.

Inhibitors of p38-a kinase

The invention is directed to prepare medicaments for treatment of and to methods to treat conditions mediated by kinase using compounds of the formula wherein Ar1 and Ph are limited to specific embodiments or wherein the compound of formula (3)