3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

Base Information

Chemical Name:3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate
CAS No.:270076-05-6
Molecular Formula:C₃₀H₃₅O₈P
Molecular Weight:554.577
Hs Code.:

Synonyms:3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

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Technology Process of 3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

There total 6 articles about 3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 100-39-0
benzyl bromide

: 270076-04-5
1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

: 270076-05-6
3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

Guidance literature:: 1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate; With potassium hydride; In tetrahydrofuran; at 0 - 20 ℃;

benzyl bromide; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1016/j.chembiol.2009.10.014

Reference yield: 70.0%

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 270076-04-5
1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

: 270076-05-6
3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

Guidance literature:: trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; at 20 ℃;
DOI:10.1016/S0040-4020(00)00065-X

Reference yield:

: 538-37-4
dibenzyl phosphochloridate

: 270076-05-6
3-O-benzyl-1,2-O-isopropylidene-3-C-methyl-α-D-ribofuranose 5-dibenzylphosphate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / CCl₄; pyridine / 3 h / 20 °C

2: 90 percent / PDC; molecular sieves; AcOH / CH₂Cl₂ / 3 h / 20 °C

3: 84 percent / tetrahydrofuran / 4 h / 20 °C

4: 70 percent / CF₃SO₃H / cyclohexane; CH₂Cl₂ / 20 °C

With dipyridinium dichromate; molecular sieve; acetic acid; trifluorormethanesulfonic acid; In tetrahydrofuran; pyridine; tetrachloromethane; dichloromethane; cyclohexane; 1: Substitution / 2: Oxidation / 3: Addition / 4: benzylation;
DOI:10.1016/S0040-4020(00)00065-X