270076-04-5Relevant academic research and scientific papers
Expression and Characterization of Soluble 4-Diphosphocytidyl-2-C-methyl-D-erythritol Kinase from Bacterial Pathogens
Eoh, Hyungjin,Narayanasamy, Prabagaran,Brown, Amanda C.,Parish, Tanya,Brennan, Patrick J.,Crick, Dean C.
, p. 1230 - 1239 (2009)
Many bacterial pathogens utilize the 2-C-methyl-D-erythritol 4-phosphate pathway for biosynthesizing isoprenoid precursors, a pathway that is vital for bacterial survival and absent from human cells, providing a potential source of drug targets. However,
Chemical synthesis of enantiopure 2-C-methyl-D-erythritol 4-phosphate, the key intermediate in the mevalonate-independent pathway for isoprenoid biosynthesis
Hoeffler, Jean-Fran?ois,Pale-Grosdemange,Rohmer, Michel
, p. 1485 - 1489 (2007/10/03)
Optically pure 2-C-methyl-D-erythritol 4-phosphate, a key intermediate in the mevalonate-independent route for isoprenoid biosynthesis, is conveniently synthesized from 1,2-O-isopropylidene-α-D-xylofuranose, including the possibility of radiolabeling of t
