(-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine

Base Information

• Chemical Name: (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine
• CAS No.: 192054-41-4
• Molecular Formula: C₁₀H₂₀N₂O
• Molecular Weight: 184.282
• Mol file: 192054-41-4.mol

Synonyms:(-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine

Chemical Property of (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine

Chemical Property:

Purity/Quality:

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Technology Process of (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine

There total 1 articles about (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-amino-2-(methoxymethyl)pyrrolidine (59983-39-0,187035-29-6) + isobutyraldehyde (78-84-2) → (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine (192054-41-4)

Guidance literature:

Yield given;

Reference yield: 77.0%

benzothiophen-2-yllithium (50779-55-0) + (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine (192054-41-4) + benzyl chloroformate (501-53-1,94274-21-2) → (1S)-(1-benzo[b]thiophen-2-yl-2-methylpropyl)carbamic acid benzyl ester (849419-08-5)

Guidance literature:

benzothiophen-2-yllithium; (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine; In diethyl ether; at -78 - 20 ℃;

With borane-THF; In tetrahydrofuran; Heating;

benzyl chloroformate; With potassium carbonate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.3987/COM-04-S(P)3

Reference yield:

cyclohexyllithium (10074-42-7) + (-)-(S)-2-(methoxymethyl)-1-(2-methylpropylideneamino)pyrrolidine (192054-41-4) → ((R)-1-Cyclohexyl-2-methyl-propyl)-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine + ((S)-1-Cyclohexyl-2-methyl-propyl)-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine

Guidance literature:

In diethyl ether; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; -78 deg C to r. t;

upstream raw materials:

(S)-1-amino-2-(methoxymethyl)pyrrolidine

isobutyraldehyde

Downstream raw materials:

(1S)-(1-benzo[b]thiophen-2-yl-2-methylpropyl)carbamic acid benzyl ester