1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

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Chemical Name:1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde
CAS No.:1518920-41-6
Molecular Formula:C₁₅H₉F₃N₂O₂
Molecular Weight:306.244
Hs Code.:

Synonyms:1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

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Chemical Property of 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

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Technology Process of 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

There total 5 articles about 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1518920-10-9
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile

: 1518920-41-6
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

Guidance literature:: 1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbonitrile; With diisobutylaluminium hydride; In dichloromethane; at -75 ℃; for 2.5h;

With rochelle salt; In dichloromethane; at -75 - 20 ℃;

Reference yield:

: 934-07-6
5-bromo-1H-pyrrole-2-carboxylic acid methyl ester

: 1518920-41-6
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: ammonium acetate; acetic acid / 130 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

3.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

4.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -75 °C

4.2: -75 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; XPhos; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5-bromo-1-[2-oxo-2-(4-trifluoromethylphenyl)-ethyl]-1H-pyrrole-2-carboxylic acid methyl ester

: 1518920-41-6
1-oxo-3-(4-trifluoromethylphenyl)-1,2-dihydro-pyrrolo[1,2-a]pyrazine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; acetic acid / 130 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere; Sealed tube

2.2: 1 h / 130 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3.1: diisobutylaluminium hydride / dichloromethane / 2.5 h / -75 °C

3.2: -75 - 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ammonium acetate; diisobutylaluminium hydride; acetic acid; XPhos; In dichloromethane; N,N-dimethyl-formamide;