benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

Base Information

Chemical Name:benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate
CAS No.:1268843-69-1
Molecular Formula:C₂₄H₂₃FO₄
Molecular Weight:394.443
Hs Code.:

Synonyms:benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

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Chemical Property of benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

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Technology Process of benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

There total 1 articles about benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268843-69-1
benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

Guidance literature:

Reference yield:

: 1268843-69-1
benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

: 1268844-22-9
C₂₄H₂₁FO₅

Guidance literature:: benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate; With sodium hypochlorite; sodium chlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; In water; acetonitrile; at 20 - 50 ℃; for 4.5h; pH=6.86; Aqueous phosphate buffer;

With citric acid; In water; acetonitrile; at 20 ℃;

Reference yield:

: 1268843-69-1
benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

: 1268841-36-6
(3R)-3-[(4'-{[4-(7-chloro-4-hydroxy-3,3-dimethyl-2-oxo-3,4-dihydro-1,5-naphthyridin-1(2H)-yl)piperidin-1-yl]carbonyl}-3'-fluorobiphenyl-2-yl)oxy]butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hypochlorite; sodium chlorite / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 4.5 h / 20 - 50 °C / pH 6.86 / Aqueous phosphate buffer

1.2: 20 °C

2.1: diisopropyl-carbodiimide / copper(l) chloride / 96 h / 20 °C / Darkness

2.2: 4.5 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 7 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With sodium hypochlorite; sodium chlorite; hydrogen; trifluoroacetic acid; diisopropyl-carbodiimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium 10% on activated carbon; copper(l) chloride; In ethanol; dichloromethane; water; acetonitrile;