benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

Base Information

Chemical Name:benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate
CAS No.:1268843-71-5
Molecular Formula:C₂₈H₂₉FO₅
Molecular Weight:464.534
Hs Code.:

Synonyms:benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

Suppliers and Price of benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

There total 2 articles about benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268844-22-9
C₂₄H₂₁FO₅

: 75-65-0
tert-butyl alcohol

: 1268843-71-5
benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

Guidance literature:: tert-butyl alcohol; With diisopropyl-carbodiimide; copper(l) chloride; at 20 ℃; for 96h; Darkness;

C₂₄H₂₁FO₅; In toluene; at 60 ℃; for 4.5h;

Reference yield:

: 1268843-69-1
benzyl 3-fluoro-2'-{[(1R)-3-hydroxy-1-methylpropyl]oxy}biphenyl-4-carboxylate

: 1268843-71-5
benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hypochlorite; sodium chlorite / 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / acetonitrile; water / 4.5 h / 20 - 50 °C / pH 6.86 / Aqueous phosphate buffer

1.2: 20 °C

2.1: diisopropyl-carbodiimide / copper(l) chloride / 96 h / 20 °C / Darkness

2.2: 4.5 h / 60 °C

With sodium hypochlorite; sodium chlorite; diisopropyl-carbodiimide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; copper(l) chloride; In water; acetonitrile;

Reference yield:

: 1268843-71-5
benzyl 2'-{[(1R)-3-tert-butoxy-1-methyl-3-oxopropyl]oxy}-3-fluorobiphenyl-4-carboxylate

: 1268841-33-3
C₃₂H₃₃ClFN₃O₆

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 7 h / 20 °C

2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / -78 - 0 °C

2.3: 5 h / 20 °C

3.1: trifluoroacetic acid; triethylsilane / dichloromethane / 6 h / 20 °C

With triethylsilane; trimethylsilyl trifluoromethanesulfonate; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In ethanol; dichloromethane;