3-Methyl-1H-indole-1-carbaldehyde

Base Information

• Chemical Name: 3-Methyl-1H-indole-1-carbaldehyde
• CAS No.: 31951-33-4
• Molecular Formula: C10H9 N O
• Molecular Weight: 159.188
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID60501124
• Nikkaji Number: J275.220D
• Wikidata: Q82353281
• Mol file: 31951-33-4.mol

Synonyms:3-Methyl-indole-1-carbaldehyde;31951-33-4;3-Methyl-1H-indole-1-carbaldehyde;3-METHYLINDOLE-1-CARBALDEHYDE;SCHEMBL349606;DTXSID60501124;AKOS006288612;AC-18685

Chemical Property of 3-Methyl-1H-indole-1-carbaldehyde

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.585
• Boiling Point: 311.139°C at 760 mmHg
• Flash Point: 141.972°C
• PSA: 22.00000
• Density: 1.108g/cm³
• LogP: 2.59010
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 159.068413911
• Heavy Atom Count: 12
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

3-METHYL-INDOLE-1-CARBALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CN(C2=CC=CC=C12)C=O

Technology Process of 3-Methyl-1H-indole-1-carbaldehyde

There total 6 articles about 3-Methyl-1H-indole-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-Methylindole (83-34-1) + formic acid (64-18-6) → 3-methyl-1H-indole-1-carbaldehyde (31951-33-4)

Guidance literature:

With aluminum oxide; at 70 ℃; for 0.75h; Neat (no solvent);

DOI:10.1039/c2gc16020j

Reference yield: 63.0%

3-Methylindole (83-34-1) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3-methyl-1H-indole-1-carbaldehyde (31951-33-4) + 2-formyl-3-methylindole (5257-24-9)

Guidance literature:

With trichlorophosphate; at 100 - 120 ℃; for 3h;

DOI:10.1002/jhet.5570370543

Reference yield: 3.0%

3-Methylindole (83-34-1) + diethoxycarbonium fluoroborate (1478-41-7) → 3-methyl-1H-indole-1-carbaldehyde (31951-33-4) + 2-formyl-3-methylindole (5257-24-9)

Guidance literature:

In diethyl ether; dichloromethane; 1) -70 deg C 2) 1.5h, -15 deg C;

DOI:10.1002/ardp.19903230205

upstream raw materials:

3-Methylindole

formic acid

diethoxycarbonium fluoroborate

N,N-dimethyl-formamide

Downstream raw materials:

3-Methyl-indole-1-carbaldehyde oxime

N-[1-(3-Methyl-indol-1-yl)-meth-(E)-ylidene]-N'-(4-nitro-phenyl)-hydrazine