(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

Base Information

Chemical Name:(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester
CAS No.:177341-35-4
Molecular Formula:C₁₉H₂₅NO₈
Molecular Weight:395.409
Hs Code.:

Synonyms:(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

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Chemical Property of (2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

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Technology Process of (2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

There total 4 articles about (2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 107-30-2
chloromethyl methyl ether

: 177341-34-3
(2S,4S,6R)-4-Hydroxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

: 177341-35-4
(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 15h;
DOI:10.1021/jo9519569

Reference yield:

: 138-60-3
chelidamic acid

: 177341-35-4
(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2-dimethoxypropane, HCl / 1.) reflux, 4 h, 2.) room temperature, overnight

2: 7.347 g / hydrogen / rhodium on alumina / H₂O / 15 h / 775.7 Torr / Ambient temperature

3: 90 percent / NaHCO₃ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

4: 94 percent / diisopropylethylamine / CH₂Cl₂ / 15 h

With hydrogenchloride; hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; 2,2-dimethoxy-propane; Rh/Al₂O₃; In dichloromethane; water;
DOI:10.1021/jo9519569

Reference yield:

: 4-Oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester; hydrochloride

: 177341-35-4
(2R,4S,6S)-4-Methoxymethoxy-piperidine-1,2,6-tricarboxylic acid benzyl ester dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.347 g / hydrogen / rhodium on alumina / H₂O / 15 h / 775.7 Torr / Ambient temperature

2: 90 percent / NaHCO₃ / CH₂Cl₂; H₂O / 4 h / Ambient temperature

3: 94 percent / diisopropylethylamine / CH₂Cl₂ / 15 h

With hydrogen; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; Rh/Al₂O₃; In dichloromethane; water;
DOI:10.1021/jo9519569