tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate
CAS No.:1470189-61-7
Molecular Formula:C₂₁H₂₉N₃O₄S
Molecular Weight:419.545
Hs Code.:

Synonyms:tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 419571-68-9
4-(3-oxo-butyrl)-piperidine-1-carboxylic acid tert-butyl ester

: 877-66-7
4-(methylsulfonyl)phenylhydrazine

: 1470189-61-7
tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

Guidance literature:: In ethanol; at 20 ℃; for 20h; Reflux; Inert atmosphere;
DOI:10.1007/s00044-013-0817-8

Reference yield:

: 498-94-2
isonipecotic acid

: 1470189-61-7
tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

4: ethanol / 20 h / 20 °C / Reflux; Inert atmosphere

With sodium hydride; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; mineral oil; 3: |Claisen Condensation;
DOI:10.1007/s00044-013-0817-8

Reference yield:

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1470189-61-7
tert-butyl 4-(3-methyl-1-(4-(methylsulphonyl)phenyl)-1H-pyrazol-5-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

3: ethanol / 20 h / 20 °C / Reflux; Inert atmosphere

With sodium hydride; In ethanol; N,N-dimethyl-formamide; mineral oil; 2: |Claisen Condensation;
DOI:10.1007/s00044-013-0817-8